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Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention

Cancer metabolism is the focus of intense research, which witnesses its key role in human tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and cancer-related mortality. This highlights the possibility that the tackling of metabolic alterations might also hold pr...

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Autores principales: Pulito, Claudio, Sanli, Toran, Rana, Punam, Muti, Paola, Blandino, Giovanni, Strano, Sabrina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937831/
https://www.ncbi.nlm.nih.gov/pubmed/24958265
http://dx.doi.org/10.3390/metabo3041051
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author Pulito, Claudio
Sanli, Toran
Rana, Punam
Muti, Paola
Blandino, Giovanni
Strano, Sabrina
author_facet Pulito, Claudio
Sanli, Toran
Rana, Punam
Muti, Paola
Blandino, Giovanni
Strano, Sabrina
author_sort Pulito, Claudio
collection PubMed
description Cancer metabolism is the focus of intense research, which witnesses its key role in human tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and cancer-related mortality. This highlights the possibility that the tackling of metabolic alterations might also hold promising value for treating cancer patients. Here, we review the emerging role of metformin as a paradigmatic example of an old drug used worldwide to treat patients with type II diabetes which to date is gaining strong in vitro and in vivo anticancer activities to be included in clinical trials. Metformin is also becoming the focus of intense basic and clinical research on chemoprevention, thus suggesting that metabolic alteration is an early lesion along cancer transformation. Metabolic reprogramming might be a very efficient prevention strategy with a profound impact on public health worldwide.
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spelling pubmed-39378312014-05-27 Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention Pulito, Claudio Sanli, Toran Rana, Punam Muti, Paola Blandino, Giovanni Strano, Sabrina Metabolites Review Cancer metabolism is the focus of intense research, which witnesses its key role in human tumors. Diabetic patients treated with metformin exhibit a reduced incidence of cancer and cancer-related mortality. This highlights the possibility that the tackling of metabolic alterations might also hold promising value for treating cancer patients. Here, we review the emerging role of metformin as a paradigmatic example of an old drug used worldwide to treat patients with type II diabetes which to date is gaining strong in vitro and in vivo anticancer activities to be included in clinical trials. Metformin is also becoming the focus of intense basic and clinical research on chemoprevention, thus suggesting that metabolic alteration is an early lesion along cancer transformation. Metabolic reprogramming might be a very efficient prevention strategy with a profound impact on public health worldwide. MDPI 2013-11-07 /pmc/articles/PMC3937831/ /pubmed/24958265 http://dx.doi.org/10.3390/metabo3041051 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pulito, Claudio
Sanli, Toran
Rana, Punam
Muti, Paola
Blandino, Giovanni
Strano, Sabrina
Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title_full Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title_fullStr Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title_full_unstemmed Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title_short Metformin: On Ongoing Journey across Diabetes, Cancer Therapy and Prevention
title_sort metformin: on ongoing journey across diabetes, cancer therapy and prevention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937831/
https://www.ncbi.nlm.nih.gov/pubmed/24958265
http://dx.doi.org/10.3390/metabo3041051
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