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Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy

Objective: To explore the value of transrectal ultrasonography (TRUS) for tumor node metastasis (TNM) restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy (neo-CRT). Methods: One hundred and forty-nine patients with locally advanced rectal cancer (cT3-4 or c...

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Autores principales: Peng, Hai-Hua, You, Kai-Yun, Wang, Cheng-Tao, Huang, Rong, Shan, Hong-Bo, Zhou, Jian-Hua, Pei, Xiao-Qing, Gao, Yuan-Hong, Wen, Bi-Xiu, Liu, Meng-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937995/
https://www.ncbi.nlm.nih.gov/pubmed/24759964
http://dx.doi.org/10.1093/gastro/got028
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author Peng, Hai-Hua
You, Kai-Yun
Wang, Cheng-Tao
Huang, Rong
Shan, Hong-Bo
Zhou, Jian-Hua
Pei, Xiao-Qing
Gao, Yuan-Hong
Wen, Bi-Xiu
Liu, Meng-Zhong
author_facet Peng, Hai-Hua
You, Kai-Yun
Wang, Cheng-Tao
Huang, Rong
Shan, Hong-Bo
Zhou, Jian-Hua
Pei, Xiao-Qing
Gao, Yuan-Hong
Wen, Bi-Xiu
Liu, Meng-Zhong
author_sort Peng, Hai-Hua
collection PubMed
description Objective: To explore the value of transrectal ultrasonography (TRUS) for tumor node metastasis (TNM) restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy (neo-CRT). Methods: One hundred and forty-nine patients with locally advanced rectal cancer (cT3-4 or cN+) who underwent TRUS after neo-CRT were retrospectively reviewed. TRUS restaging was compared with the results of post-operative pathological TNM findings. Results: After neo-CRT, the accuracy of TRUS for diagnosing T-staging was 30.9%, with 60.4% (90/149) of cases overestimated. The sensitivity of TRUS for T-staging (T0 vs T1 vs T2 vs T3 vs T4) were 16.3%, 0%, 12.5%, 42.6% and 75.0%, respectively. The accuracy of TRUS for diagnosing N-staging after neo-CRT was 81.2%, with the sensitivities of N0 and N+ were 93.3% and 31.0%, respectively. After neo-CRT, 27.5% (41/149) of patients achieved pathologically complete response (pCR). The sensitivity, specificity, positive predictive value and negative predictive values of TRUS for pCR were 17.1%, 99.1%, 87.5% and 75.9%, respectively. Conclusions: TRUS can be applied for restaging T4 and N0, and has potential for screening out patients with pCR in those with locally advanced rectal cancer after neo-CRT, although some stages are overestimated for T-staging and its sensitivity for predicting pCR is low.
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spelling pubmed-39379952014-03-04 Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy Peng, Hai-Hua You, Kai-Yun Wang, Cheng-Tao Huang, Rong Shan, Hong-Bo Zhou, Jian-Hua Pei, Xiao-Qing Gao, Yuan-Hong Wen, Bi-Xiu Liu, Meng-Zhong Gastroenterol Rep (Oxf) Original Articles Objective: To explore the value of transrectal ultrasonography (TRUS) for tumor node metastasis (TNM) restaging for patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy (neo-CRT). Methods: One hundred and forty-nine patients with locally advanced rectal cancer (cT3-4 or cN+) who underwent TRUS after neo-CRT were retrospectively reviewed. TRUS restaging was compared with the results of post-operative pathological TNM findings. Results: After neo-CRT, the accuracy of TRUS for diagnosing T-staging was 30.9%, with 60.4% (90/149) of cases overestimated. The sensitivity of TRUS for T-staging (T0 vs T1 vs T2 vs T3 vs T4) were 16.3%, 0%, 12.5%, 42.6% and 75.0%, respectively. The accuracy of TRUS for diagnosing N-staging after neo-CRT was 81.2%, with the sensitivities of N0 and N+ were 93.3% and 31.0%, respectively. After neo-CRT, 27.5% (41/149) of patients achieved pathologically complete response (pCR). The sensitivity, specificity, positive predictive value and negative predictive values of TRUS for pCR were 17.1%, 99.1%, 87.5% and 75.9%, respectively. Conclusions: TRUS can be applied for restaging T4 and N0, and has potential for screening out patients with pCR in those with locally advanced rectal cancer after neo-CRT, although some stages are overestimated for T-staging and its sensitivity for predicting pCR is low. Oxford University Press 2013-11 2013-10-23 /pmc/articles/PMC3937995/ /pubmed/24759964 http://dx.doi.org/10.1093/gastro/got028 Text en © The Author(s) 2013. Published by Oxford University Press and the Digestive Science Publishing Co. Limited. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Peng, Hai-Hua
You, Kai-Yun
Wang, Cheng-Tao
Huang, Rong
Shan, Hong-Bo
Zhou, Jian-Hua
Pei, Xiao-Qing
Gao, Yuan-Hong
Wen, Bi-Xiu
Liu, Meng-Zhong
Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title_full Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title_fullStr Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title_full_unstemmed Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title_short Value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
title_sort value of transrectal ultrasonography for tumor node metastasis restaging in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937995/
https://www.ncbi.nlm.nih.gov/pubmed/24759964
http://dx.doi.org/10.1093/gastro/got028
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