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Endoscopic findings in uninvestigated dyspepsia

BACKGROUND: It is important to know the causes of dyspepsia to establish the therapeutic approach. Dyspepsia is a frequent syndrome in our country, where there are restrictions to endoscopy and high prevalence of Helicobacter pylori (H. pylori) infection. This study aimed to assess the endoscopic fi...

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Autores principales: Faintuch, Jacob Jehuda, Silva, Fernando Marcuz, Navarro-Rodriguez, Tomás, Barbuti, Ricardo Correa, Hashimoto, Claudio Lyoiti, Rossini, Alessandra Rita Asayama Lopes, Diniz, Marcio Augusto, Eisig, Jaime Natan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938027/
https://www.ncbi.nlm.nih.gov/pubmed/24499444
http://dx.doi.org/10.1186/1471-230X-14-19
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author Faintuch, Jacob Jehuda
Silva, Fernando Marcuz
Navarro-Rodriguez, Tomás
Barbuti, Ricardo Correa
Hashimoto, Claudio Lyoiti
Rossini, Alessandra Rita Asayama Lopes
Diniz, Marcio Augusto
Eisig, Jaime Natan
author_facet Faintuch, Jacob Jehuda
Silva, Fernando Marcuz
Navarro-Rodriguez, Tomás
Barbuti, Ricardo Correa
Hashimoto, Claudio Lyoiti
Rossini, Alessandra Rita Asayama Lopes
Diniz, Marcio Augusto
Eisig, Jaime Natan
author_sort Faintuch, Jacob Jehuda
collection PubMed
description BACKGROUND: It is important to know the causes of dyspepsia to establish the therapeutic approach. Dyspepsia is a frequent syndrome in our country, where there are restrictions to endoscopy and high prevalence of Helicobacter pylori (H. pylori) infection. This study aimed to assess the endoscopic findings of the syndrome, in an outpatient screening clinic of a tertiary hospital in São Paulo. METHODS: Outpatients with uninvestigated dyspepsia, according to Rome III criteria, answered a dyspepsia questionnaire and underwent esophagogastroduodenoscopy. The Rapid Urease Test was applied to fragments of the antral mucosa and epidemiological data were collected from the studied population. Organic dyspepsia findings were analyzed with different variables to verify statistically significant associations. RESULTS: Three hundred and six patients were included and 282 were analyzed in the study. The mean age was 44 years and women comprised 65% of the sample. Forty-five percent of the patients reported alarm symptoms. Functional dyspepsia was found in 66% of the patients (20% with normal endoscopy results and 46% with gastritis), 18% had GERD and 13% had ulcers (duodenal in 9% and gastric in 4%). Four cases of gastric adenocarcinoma were identified (1.4%), one without alarm characteristics, 1 case of adenocarcinoma of the distal esophagus and 1 case of gastric lymphoma. The prevalence of H. pylori was 54% and infection, age and smoking status were associated with organic dyspepsia. The age of 48 years was indicative of alarm signs. CONCLUSIONS: The endoscopic diagnosis of uninvestigated dyspepsia in our setting showed a predominance of functional disease, whereas cancer was an uncommon finding, despite the high prevalence of H. pylori. Organic dyspepsia was associated with infection, age and smoking status.
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spelling pubmed-39380272014-03-01 Endoscopic findings in uninvestigated dyspepsia Faintuch, Jacob Jehuda Silva, Fernando Marcuz Navarro-Rodriguez, Tomás Barbuti, Ricardo Correa Hashimoto, Claudio Lyoiti Rossini, Alessandra Rita Asayama Lopes Diniz, Marcio Augusto Eisig, Jaime Natan BMC Gastroenterol Research Article BACKGROUND: It is important to know the causes of dyspepsia to establish the therapeutic approach. Dyspepsia is a frequent syndrome in our country, where there are restrictions to endoscopy and high prevalence of Helicobacter pylori (H. pylori) infection. This study aimed to assess the endoscopic findings of the syndrome, in an outpatient screening clinic of a tertiary hospital in São Paulo. METHODS: Outpatients with uninvestigated dyspepsia, according to Rome III criteria, answered a dyspepsia questionnaire and underwent esophagogastroduodenoscopy. The Rapid Urease Test was applied to fragments of the antral mucosa and epidemiological data were collected from the studied population. Organic dyspepsia findings were analyzed with different variables to verify statistically significant associations. RESULTS: Three hundred and six patients were included and 282 were analyzed in the study. The mean age was 44 years and women comprised 65% of the sample. Forty-five percent of the patients reported alarm symptoms. Functional dyspepsia was found in 66% of the patients (20% with normal endoscopy results and 46% with gastritis), 18% had GERD and 13% had ulcers (duodenal in 9% and gastric in 4%). Four cases of gastric adenocarcinoma were identified (1.4%), one without alarm characteristics, 1 case of adenocarcinoma of the distal esophagus and 1 case of gastric lymphoma. The prevalence of H. pylori was 54% and infection, age and smoking status were associated with organic dyspepsia. The age of 48 years was indicative of alarm signs. CONCLUSIONS: The endoscopic diagnosis of uninvestigated dyspepsia in our setting showed a predominance of functional disease, whereas cancer was an uncommon finding, despite the high prevalence of H. pylori. Organic dyspepsia was associated with infection, age and smoking status. BioMed Central 2014-02-06 /pmc/articles/PMC3938027/ /pubmed/24499444 http://dx.doi.org/10.1186/1471-230X-14-19 Text en Copyright © 2014 Faintuch et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Faintuch, Jacob Jehuda
Silva, Fernando Marcuz
Navarro-Rodriguez, Tomás
Barbuti, Ricardo Correa
Hashimoto, Claudio Lyoiti
Rossini, Alessandra Rita Asayama Lopes
Diniz, Marcio Augusto
Eisig, Jaime Natan
Endoscopic findings in uninvestigated dyspepsia
title Endoscopic findings in uninvestigated dyspepsia
title_full Endoscopic findings in uninvestigated dyspepsia
title_fullStr Endoscopic findings in uninvestigated dyspepsia
title_full_unstemmed Endoscopic findings in uninvestigated dyspepsia
title_short Endoscopic findings in uninvestigated dyspepsia
title_sort endoscopic findings in uninvestigated dyspepsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938027/
https://www.ncbi.nlm.nih.gov/pubmed/24499444
http://dx.doi.org/10.1186/1471-230X-14-19
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