Tempol, an Intracellular Antioxidant, Inhibits Tissue Factor Expression, Attenuates Dendritic Cell Function, and Is Partially Protective in a Murine Model of Cerebral Malaria

BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol—a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant—in cells relevant to malaria p...

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Detalles Bibliográficos
Autores principales: Francischetti, Ivo M. B., Gordon, Emile, Bizzarro, Bruna, Gera, Nidhi, Andrade, Bruno B., Oliveira, Fabiano, Ma, Dongying, Assumpção, Teresa C. F., Ribeiro, José M. C., Pena, Mirna, Qi, Chen-Feng, Diouf, Ababacar, Moretz, Samuel E., Long, Carole A., Ackerman, Hans C., Pierce, Susan K., Sá-Nunes, Anderson, Waisberg, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938406/
https://www.ncbi.nlm.nih.gov/pubmed/24586264
http://dx.doi.org/10.1371/journal.pone.0087140

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