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Establishment of Real Time Allele Specific Locked Nucleic Acid Quantitative PCR for Detection of HBV YIDD (ATT) Mutation and Evaluation of Its Application

BACKGROUND: Long-term use of nucleos(t)ide analogues can increase risk of HBV drug-resistance mutations. The rtM204I (ATT coding for isoleucine) is one of the most important resistance mutation sites. Establishing a simple, rapid, reliable and highly sensitive assay to detect the resistant mutants a...

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Detalles Bibliográficos
Autores principales:	Zeng, Yongbin, Li, Dezhong, Wang, Wei, Su, Mingkuan, Lin, Jinpiao, Chen, Huijuan, Jiang, Ling, Chen, Jing, Yang, Bin, Ou, Qishui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938556/ https://www.ncbi.nlm.nih.gov/pubmed/24587198 http://dx.doi.org/10.1371/journal.pone.0090029

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