Cargando…

Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats

Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by coil. Bone marrow–derived endothelial progenitor cel...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Song, An, Qingzhu, Li, Qianyun, Huang, Jun, Chen, Xi, Chen, Xiaoyan, Zhang, Jun, Wang, Yongting, Yang, Guo-Yuan, Zhu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938595/
https://www.ncbi.nlm.nih.gov/pubmed/24587209
http://dx.doi.org/10.1371/journal.pone.0090069
_version_ 1782305626571931648
author Zhang, Song
An, Qingzhu
Li, Qianyun
Huang, Jun
Chen, Xi
Chen, Xiaoyan
Zhang, Jun
Wang, Yongting
Yang, Guo-Yuan
Zhu, Wei
author_facet Zhang, Song
An, Qingzhu
Li, Qianyun
Huang, Jun
Chen, Xi
Chen, Xiaoyan
Zhang, Jun
Wang, Yongting
Yang, Guo-Yuan
Zhu, Wei
author_sort Zhang, Song
collection PubMed
description Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by coil. Bone marrow–derived endothelial progenitor cells (BM-EPCs) could be incorporated into injured endothelium and differentiate into mature endothelial cells during vascular repairing processes. The aim of our study is to explore the effects of BM-EPCs on aneurysm repairing and remodeling in a rat embolization model of abdominal aortic aneurysm. BM-EPC proliferation, migration and tube formation were not affected by super-paramagnetic iron oxide nanoparticle (SPIO) labeling compared to the controls (p>0.05). The number of SPIO-labeled cells greatly increased in EPC transplanted rats compared to that of phosphate buffered saline treated rats. SPIO-labeled EPC (SPIO-EPC) are mainly located in the aneurysm neck and surrounded by fibrous tissue. A histology study showed that the aneurysm orifice was closed with neointima and the aneurysm was filled with newly formed fibrous tissue. The SPIO-EPC accumulated in the aneurysm neck, which accelerated focal fibrous tissue remodeling, suggesting that BM-EPCs play a crucial role in repairing and remodeling the aneurysm neck orifice.
format Online
Article
Text
id pubmed-3938595
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-39385952014-03-04 Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats Zhang, Song An, Qingzhu Li, Qianyun Huang, Jun Chen, Xi Chen, Xiaoyan Zhang, Jun Wang, Yongting Yang, Guo-Yuan Zhu, Wei PLoS One Research Article Aneurysm embolization with coil is now widely used clinically. However, the recurrence of aneurysms after embolization has always plagued neurosurgeons because the endothelial layer of the aneurysm neck loses its integrity after being embolized by coil. Bone marrow–derived endothelial progenitor cells (BM-EPCs) could be incorporated into injured endothelium and differentiate into mature endothelial cells during vascular repairing processes. The aim of our study is to explore the effects of BM-EPCs on aneurysm repairing and remodeling in a rat embolization model of abdominal aortic aneurysm. BM-EPC proliferation, migration and tube formation were not affected by super-paramagnetic iron oxide nanoparticle (SPIO) labeling compared to the controls (p>0.05). The number of SPIO-labeled cells greatly increased in EPC transplanted rats compared to that of phosphate buffered saline treated rats. SPIO-labeled EPC (SPIO-EPC) are mainly located in the aneurysm neck and surrounded by fibrous tissue. A histology study showed that the aneurysm orifice was closed with neointima and the aneurysm was filled with newly formed fibrous tissue. The SPIO-EPC accumulated in the aneurysm neck, which accelerated focal fibrous tissue remodeling, suggesting that BM-EPCs play a crucial role in repairing and remodeling the aneurysm neck orifice. Public Library of Science 2014-02-28 /pmc/articles/PMC3938595/ /pubmed/24587209 http://dx.doi.org/10.1371/journal.pone.0090069 Text en © 2014 Zhang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhang, Song
An, Qingzhu
Li, Qianyun
Huang, Jun
Chen, Xi
Chen, Xiaoyan
Zhang, Jun
Wang, Yongting
Yang, Guo-Yuan
Zhu, Wei
Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title_full Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title_fullStr Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title_full_unstemmed Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title_short Therapeutic Benefit of Bone Marrow–Derived Endothelial Progenitor Cell Transplantation after Experimental Aneurysm Embolization with Coil in Rats
title_sort therapeutic benefit of bone marrow–derived endothelial progenitor cell transplantation after experimental aneurysm embolization with coil in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938595/
https://www.ncbi.nlm.nih.gov/pubmed/24587209
http://dx.doi.org/10.1371/journal.pone.0090069
work_keys_str_mv AT zhangsong therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT anqingzhu therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT liqianyun therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT huangjun therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT chenxi therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT chenxiaoyan therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT zhangjun therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT wangyongting therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT yangguoyuan therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats
AT zhuwei therapeuticbenefitofbonemarrowderivedendothelialprogenitorcelltransplantationafterexperimentalaneurysmembolizationwithcoilinrats