HIV-1 Adenoviral Vector Vaccines Expressing Multi-Trimeric BAFF and 4-1BBL Enhance T Cell Mediated Anti-Viral Immunity

Adenoviral vectored vaccines have shown considerable promise but could be improved by molecular adjuvants. Ligands in the TNF superfamily (TNFSF) are potential adjuvants for adenoviral vector (Ad5) vaccines based on their central role in adaptive immunity. Many TNFSF ligands require aggregation beyo...

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Detalles Bibliográficos
Autores principales: Kanagavelu, Saravana, Termini, James M., Gupta, Sachin, Raffa, Francesca N., Fuller, Katherine A., Rivas, Yaelis, Philip, Sakhi, Kornbluth, Richard S., Stone, Geoffrey W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938597/
https://www.ncbi.nlm.nih.gov/pubmed/24587225
http://dx.doi.org/10.1371/journal.pone.0090100

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