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Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)

OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. METHODS: Altogether 131 subjects (40–70 y, BMI 26–39 kg/m(2)) with impaired glucose metabolism and features of the m...

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Autores principales: Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J., Soininen, Pasi, Poutanen, Kaisa, Mykkänen, Hannu, Gylling, Helena, Orešič, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, Schwab, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938672/
https://www.ncbi.nlm.nih.gov/pubmed/24587337
http://dx.doi.org/10.1371/journal.pone.0090352
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author Lankinen, Maria
Kolehmainen, Marjukka
Jääskeläinen, Tiina
Paananen, Jussi
Joukamo, Laura
Kangas, Antti J.
Soininen, Pasi
Poutanen, Kaisa
Mykkänen, Hannu
Gylling, Helena
Orešič, Matej
Jauhiainen, Matti
Ala-Korpela, Mika
Uusitupa, Matti
Schwab, Ursula
author_facet Lankinen, Maria
Kolehmainen, Marjukka
Jääskeläinen, Tiina
Paananen, Jussi
Joukamo, Laura
Kangas, Antti J.
Soininen, Pasi
Poutanen, Kaisa
Mykkänen, Hannu
Gylling, Helena
Orešič, Matej
Jauhiainen, Matti
Ala-Korpela, Mika
Uusitupa, Matti
Schwab, Ursula
author_sort Lankinen, Maria
collection PubMed
description OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. METHODS: Altogether 131 subjects (40–70 y, BMI 26–39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites. RESULTS: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. CONCLUSIONS: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis. TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov NCT00573781.
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spelling pubmed-39386722014-03-04 Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet) Lankinen, Maria Kolehmainen, Marjukka Jääskeläinen, Tiina Paananen, Jussi Joukamo, Laura Kangas, Antti J. Soininen, Pasi Poutanen, Kaisa Mykkänen, Hannu Gylling, Helena Orešič, Matej Jauhiainen, Matti Ala-Korpela, Mika Uusitupa, Matti Schwab, Ursula PLoS One Research Article OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. METHODS: Altogether 131 subjects (40–70 y, BMI 26–39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites. RESULTS: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. CONCLUSIONS: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis. TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov NCT00573781. Public Library of Science 2014-02-28 /pmc/articles/PMC3938672/ /pubmed/24587337 http://dx.doi.org/10.1371/journal.pone.0090352 Text en © 2014 Lankinen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Lankinen, Maria
Kolehmainen, Marjukka
Jääskeläinen, Tiina
Paananen, Jussi
Joukamo, Laura
Kangas, Antti J.
Soininen, Pasi
Poutanen, Kaisa
Mykkänen, Hannu
Gylling, Helena
Orešič, Matej
Jauhiainen, Matti
Ala-Korpela, Mika
Uusitupa, Matti
Schwab, Ursula
Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title_full Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title_fullStr Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title_full_unstemmed Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title_short Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)
title_sort effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (sysdimet)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938672/
https://www.ncbi.nlm.nih.gov/pubmed/24587337
http://dx.doi.org/10.1371/journal.pone.0090352
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