Tumour Necrosis Factor-α Regulates Human Eosinophil Apoptosis via Ligation of TNF-Receptor 1 and Balance between NF-κB and AP-1

Eosinophils play a central role in asthma. The present study was performed to investigate the effect of tumour necrosis factor-α (TNF-α) on longevity of isolated human eosinophils. In contrast to Fas, TNF-α inhibited eosinophil apoptosis as evidenced by a combination of flow cytometry, DNA fragmenta...

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Detalles Bibliográficos
Autores principales: Kankaanranta, Hannu, Ilmarinen, Pinja, Zhang, Xianzhi, Adcock, Ian M., Lahti, Aleksi, Barnes, Peter J., Giembycz, Mark A., Lindsay, Mark A., Moilanen, Eeva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938678/
https://www.ncbi.nlm.nih.gov/pubmed/24587316
http://dx.doi.org/10.1371/journal.pone.0090298

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