Cargando…

An mDia2/ROCK Signaling Axis Regulates Invasive Egress from Epithelial Ovarian Cancer Spheroids

Multi-cellular spheroids are enriched in ascites of epithelial ovarian cancer (OvCa) patients. They represent an invasive and chemoresistant cellular population fundamental to metastatic dissemination. The molecular mechanisms triggering single cell invasive egress from spheroids remain enigmatic. m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pettee, Krista M., Dvorak, Kaitlyn M., Nestor-Kalinoski, Andrea L., Eisenmann, Kathryn M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938721/ https://www.ncbi.nlm.nih.gov/pubmed/24587343 http://dx.doi.org/10.1371/journal.pone.0090371

Ejemplares similares

Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2)
por: Dvorak, Kaitlyn M., et al.
Publicado: (2018)

Dia-Interacting Protein (DIP) Imposes Migratory Plasticity in mDia2-Dependent Tumor Cells in Three-Dimensional Matrices
por: Wyse, Meghan M., et al.
Publicado: (2012)

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells
por: Becker, Kathryn N., et al.
Publicado: (2022)

Targeting the mDia Formin-Assembled Cytoskeleton Is an Effective Anti-Invasion Strategy in Adult High-Grade Glioma Patient-Derived Neurospheres
por: Pettee, Krista M., et al.
Publicado: (2019)

Small-molecule agonists of mammalian Diaphanous–related (mDia) formins reveal an effective glioblastoma anti-invasion strategy
por: Arden, Jessica D., et al.
Publicado: (2015)

Differential interactions of the formins INF2, mDia1, and mDia2 with microtubules
por: Gaillard, Jeremie, et al.
Publicado: (2011)

Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish
por: LeCorgne, Hunter, et al.
Publicado: (2018)

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments
por: Meiring, Joyce C. M., et al.
Publicado: (2019)

mDia1-3 in mammalian filopodia
por: Goh, Wah Ing, et al.
Publicado: (2012)

ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts
por: Tsuji, Takahiro, et al.
Publicado: (2002)

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK
por: Salinas, Romina P., et al.
Publicado: (2015)

Crystal Structure of the Formin mDia1 in Autoinhibited Conformation
por: Otomo, Takanori, et al.
Publicado: (2010)

mDia1 and formins: screw cap of the actin filament
por: Mizuno, Hiroaki, et al.
Publicado: (2012)

Geometrical Constraints Greatly Hinder Formin mDia1 Activity
por: Suzuki, Emiko L., et al.
Publicado: (2019)

A paracrine activin A–mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming
por: Cangkrama, Michael, et al.
Publicado: (2020)

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function
por: Barzik, Melanie, et al.
Publicado: (2014)

Rho and Anillin-dependent Control of mDia2 Localization and Function in Cytokinesis
por: Watanabe, Sadanori, et al.
Publicado: (2010)

Targeting secretion to the apical surface by mDia1-built actin tracks
por: Geron, Erez, et al.
Publicado: (2013)

Diaphanous formin mDia2 regulates CENP-A levels at centromeres
por: Liu, Chenshu, et al.
Publicado: (2016)

A Protumorigenic mDia2–MIRO1 Axis Controls Mitochondrial Positioning and Function in Cancer-Associated Fibroblasts
por: Cangkrama, Michael, et al.
Publicado: (2022)

Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells
por: Yang, Changsong, et al.
Publicado: (2007)

The formin mDia2 stabilizes microtubules independently of its actin nucleation activity
por: Bartolini, Francesca, et al.
Publicado: (2008)

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1
por: Sakata, Daiji, et al.
Publicado: (2007)

Involvement of the Rho–mDia1 pathway in the regulation of Golgi complex architecture and dynamics
por: Zilberman, Yuliya, et al.
Publicado: (2011)

Deficiency of mDia, an Actin Nucleator, Disrupts Integrity of Neuroepithelium and Causes Periventricular Dysplasia
por: Thumkeo, Dean, et al.
Publicado: (2011)

Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function
por: Zuidscherwoude, Malou, et al.
Publicado: (2020)

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
por: Okada, Kyoko, et al.
Publicado: (2010)

mDia1 senses both force and torque during F-actin filament polymerization
por: Yu, Miao, et al.
Publicado: (2017)

Actin-capping protein promotes microtubule stability by antagonizing the actin activity of mDia1
por: Bartolini, Francesca, et al.
Publicado: (2012)

Neuronal drebrin A directly interacts with mDia2 formin to inhibit actin assembly
por: Ginosyan, Anush A., et al.
Publicado: (2019)

The Formin mDia1 Regulates Acute Lymphoblastic Leukemia Engraftment, Migration, and Progression in vivo
por: Thompson, Scott B., et al.
Publicado: (2018)

Formin Activity and mDia1 Contribute to Maintain Axon Initial Segment Composition and Structure
por: Zhang, Wei, et al.
Publicado: (2021)

Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains
por: Gorelik, Roman, et al.
Publicado: (2011)

Kif4 Interacts with EB1 and Stabilizes Microtubules Downstream of Rho-mDia in Migrating Fibroblasts
por: Morris, Edward J., et al.
Publicado: (2014)

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin
por: Mizuno, Hiroaki, et al.
Publicado: (2018)

Nuclear Actin Polymerized by mDia2 Confines Centromere Movement during CENP-A Loading
por: Liu, Chenshu, et al.
Publicado: (2018)

mDia1/3-dependent actin polymerization spatiotemporally controls LAT phosphorylation by Zap70 at the immune synapse
por: Thumkeo, D., et al.
Publicado: (2020)

mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization
por: Kim, Daehwan, et al.
Publicado: (2016)

Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity
por: Qu, Xiaoyi, et al.
Publicado: (2017)

Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2
por: Li, Xuehui, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nas0rldn6h9ocrrnjegmetvgrd