Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression

MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known....

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Autores principales: Veerappa, Avinash M., N, Megha Murthy, Vishweswaraiah, Sangeetha, Lingaiah, Kusuma, Suresh, Raviraj V., Nachappa, Somanna Ajjamada, Prashali, Nelchi, Yadav, Sangeetha Nuggehalli, Srikanta, Manjula Arsikere, Manjegowda, Dinesh S., Seshachalam, Keshava B., Ramachandra, Nallur B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938728/
https://www.ncbi.nlm.nih.gov/pubmed/24587348
http://dx.doi.org/10.1371/journal.pone.0090391
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author Veerappa, Avinash M.
N, Megha Murthy
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Suresh, Raviraj V.
Nachappa, Somanna Ajjamada
Prashali, Nelchi
Yadav, Sangeetha Nuggehalli
Srikanta, Manjula Arsikere
Manjegowda, Dinesh S.
Seshachalam, Keshava B.
Ramachandra, Nallur B.
author_facet Veerappa, Avinash M.
N, Megha Murthy
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Suresh, Raviraj V.
Nachappa, Somanna Ajjamada
Prashali, Nelchi
Yadav, Sangeetha Nuggehalli
Srikanta, Manjula Arsikere
Manjegowda, Dinesh S.
Seshachalam, Keshava B.
Ramachandra, Nallur B.
author_sort Veerappa, Avinash M.
collection PubMed
description MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known. From a total of 44109 CNVs investigated from 1715 individuals across 12 populations using high-throughput arrays, 4007 miRNA-CNVs (∼9%) consisting 6542 (∼5%) miRNA genes with a total of 333 (∼5%) singleton miRNA genes were identified. We found miRNA-CNVs across the genomes of individuals showing multiple hits in many targets, co-regulated under the same pathway. This study proposes four mechanisms unraveling the many complexities in miRNA genes, targets and co-regulated miRNA genes towards establishment of phenotypic diversity.
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spelling pubmed-39387282014-03-04 Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression Veerappa, Avinash M. N, Megha Murthy Vishweswaraiah, Sangeetha Lingaiah, Kusuma Suresh, Raviraj V. Nachappa, Somanna Ajjamada Prashali, Nelchi Yadav, Sangeetha Nuggehalli Srikanta, Manjula Arsikere Manjegowda, Dinesh S. Seshachalam, Keshava B. Ramachandra, Nallur B. PLoS One Research Article MicroRNAs are involved in post-transcriptional down-regulation of gene expression. Variations in miRNA genes can severely affect downstream-regulated genes and their pathways. However, population-specific burden of CNVs on miRNA genes and the complexities created towards the phenotype is not known. From a total of 44109 CNVs investigated from 1715 individuals across 12 populations using high-throughput arrays, 4007 miRNA-CNVs (∼9%) consisting 6542 (∼5%) miRNA genes with a total of 333 (∼5%) singleton miRNA genes were identified. We found miRNA-CNVs across the genomes of individuals showing multiple hits in many targets, co-regulated under the same pathway. This study proposes four mechanisms unraveling the many complexities in miRNA genes, targets and co-regulated miRNA genes towards establishment of phenotypic diversity. Public Library of Science 2014-02-28 /pmc/articles/PMC3938728/ /pubmed/24587348 http://dx.doi.org/10.1371/journal.pone.0090391 Text en © 2014 Veerappa et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Veerappa, Avinash M.
N, Megha Murthy
Vishweswaraiah, Sangeetha
Lingaiah, Kusuma
Suresh, Raviraj V.
Nachappa, Somanna Ajjamada
Prashali, Nelchi
Yadav, Sangeetha Nuggehalli
Srikanta, Manjula Arsikere
Manjegowda, Dinesh S.
Seshachalam, Keshava B.
Ramachandra, Nallur B.
Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title_full Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title_fullStr Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title_full_unstemmed Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title_short Copy Number Variations Burden on miRNA Genes Reveals Layers of Complexities Involved in the Regulation of Pathways and Phenotypic Expression
title_sort copy number variations burden on mirna genes reveals layers of complexities involved in the regulation of pathways and phenotypic expression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938728/
https://www.ncbi.nlm.nih.gov/pubmed/24587348
http://dx.doi.org/10.1371/journal.pone.0090391
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