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Reducing ppGpp Level Rescues an Extreme Growth Defect Caused by Mutant EF-Tu
Transcription and translation of mRNA's are coordinated processes in bacteria. We have previously shown that a mutant form of EF-Tu (Gln125Arg) in Salmonella Typhimurium with a reduced affinity for aa-tRNA, causes ribosome pausing, resulting in an increased rate of RNase E-mediated mRNA cleavag...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938759/ https://www.ncbi.nlm.nih.gov/pubmed/24587376 http://dx.doi.org/10.1371/journal.pone.0090486 |