Suppression of Immunodominant Antitumor and Antiviral CD8(+) T Cell Responses by Indoleamine 2,3-Dioxygenase

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme known to suppress antitumor CD8(+) T cells (T(CD8)). The role of IDO in regulation of antiviral T(CD8) responses is far less clear. In addition, whether IDO controls both immunodominant and subdominant T(CD8) is not fully understood....

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Detalles Bibliográficos
Autores principales: Rytelewski, Mateusz, Meilleur, Courtney E., Atef Yekta, Maryam, Szabo, Peter A., Garg, Nitan, Schell, Todd D., Jevnikar, Anthony M., Sharif, Shayan, Singh, Bhagirath, Haeryfar, S. M. Mansour
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938761/
https://www.ncbi.nlm.nih.gov/pubmed/24587363
http://dx.doi.org/10.1371/journal.pone.0090439

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