Cargando…

De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors

Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2) maintains gene repres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smadbeck, James, Peterson, Meghan B., Zee, Barry M., Garapaty, Shivani, Mago, Aashna, Lee, Christina, Giannis, Athanassios, Trojer, Patrick, Garcia, Benjamin A., Floudas, Christodoulos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938834/ https://www.ncbi.nlm.nih.gov/pubmed/24587223 http://dx.doi.org/10.1371/journal.pone.0090095

Ejemplares similares

De Novo Design and Experimental Characterization of Ultrashort Self-Associating Peptides
por: Smadbeck, James, et al.
Publicado: (2014)

Correction: De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors
Publicado: (2014)

Forcefield_NCAA: Ab Initio Charge Parameters to Aid in the Discovery and Design of Therapeutic Proteins and Peptides with Unnatural Amino Acids and Their Application to Complement Inhibitors of the Compstatin Family
por: Khoury, George A., et al.
Publicado: (2014)

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
por: Li, Yan, et al.
Publicado: (2009)

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a
por: Halai, Reena, et al.
Publicado: (2014)

Identification of a peptide inhibitor for the histone methyltransferase WHSC1
por: Morrison, Michael J., et al.
Publicado: (2018)

Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins
por: Trojer, Patrick, et al.
Publicado: (2009)

Deterministic global optimization: theory, methods and applications
por: Floudas, Christodoulos A
Publicado: (2000)

Kupffer and stellate cell proteoglycans mediate malaria sporozoite targeting to the liver
por: Pradel, Gabriele, et al.
Publicado: (2004)

Encyclopedia of optimization
por: Floudas, Christodoulos, et al.
Publicado: (2001)

Encyclopedia of optimization
por: Floudas, Christodoulos, et al.
Publicado: (2009)

Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
por: Kanwal, Rajnee, et al.
Publicado: (2016)

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
por: Zhou, Jie, et al.
Publicado: (2019)

The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis
por: Liu, Min, et al.
Publicado: (2021)

β-sheet Topology Prediction with High Precision and Recall for β and Mixed α/β Proteins
por: Subramani, Ashwin, et al.
Publicado: (2012)

Molecular Recognition of CCR5 by an HIV-1 gp120 V3 Loop
por: Tamamis, Phanourios, et al.
Publicado: (2014)

Elucidating a Key Component of Cancer Metastasis: CXCL12 (SDF-1α) Binding to CXCR4
por: Tamamis, Phanourios, et al.
Publicado: (2014)

Elucidating a Key Anti-HIV-1 and Cancer-Associated Axis: The Structure of CCL5 (Rantes) in Complex with CCR5
por: Tamamis, Phanourios, et al.
Publicado: (2014)

A Comparative Theoretical and Computational Study on Robust Counterpart Optimization: III. Improving the Quality of Robust Solutions
por: Li, Zukui, et al.
Publicado: (2014)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
por: Kawamura, Akane, et al.
Publicado: (2017)

Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors
por: Whitmore, Melanie A., et al.
Publicado: (2022)

Covalent inhibition of NSD1 histone methyltransferase
por: Huang, Huang, et al.
Publicado: (2020)

New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics
por: Gorham, Ronald D., et al.
Publicado: (2014)

Correction: Dietary Flavones as Dual Inhibitors of DNA Methyltransferases and Histone Methyltransferases
por: Kanwal, Rajnee, et al.
Publicado: (2016)

Chemical Probes of Histone Lysine Methyltransferases
por: Kaniskan, H. Ümit, et al.
Publicado: (2014)

Histone methyltransferase and drug resistance in cancers
por: Yang, Cheng, et al.
Publicado: (2020)

Lysine Ethylation by Histone Lysine Methyltransferases
por: Al Temimi, Abbas H. K., et al.
Publicado: (2019)

A quantitative atlas of histone modification signatures from human cancer cells
por: LeRoy, Gary, et al.
Publicado: (2013)

Optimization in science and engineering: in honor of the 60th birthday of Panos M. Pardalos
por: Rassias, Themistocles, et al.
Publicado: (2014)

BRAF inhibition in melanoma is associated with the dysregulation of histone methylation and histone methyltransferases
por: Grigore, Florina, et al.
Publicado: (2020)

Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
por: Yu, Chao, et al.
Publicado: (2019)

Histone Methyltransferases Useful in Gastric Cancer Research
por: Reyes, Dafne Alejandra, et al.
Publicado: (2021)

The histone methyltransferase SETD2 negatively regulates cell size
por: Molenaar, Thom M., et al.
Publicado: (2022)

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases
por: Zhang, Pamela, et al.
Publicado: (2012)

De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
por: Vinson, David A., et al.
Publicado: (2022)

Proteomic Interrogation of Human Chromatin
por: Torrente, Mariana P., et al.
Publicado: (2011)

The histone methyltransferase SET8 is required for S-phase progression
por: Jørgensen, Stine, et al.
Publicado: (2007)

Role of several histone lysine methyltransferases in tumor development
por: LI, JIFU, et al.
Publicado: (2016)

The role of histone lysine methyltransferase NSD3 in cancer
por: Han, Xu, et al.
Publicado: (2018)

Histone methyltransferase SMYD2: ubiquitous regulator of disease
por: Yi, Xin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cs0q1aoqc9n8f5gjcvqd99blh7