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De Novo Peptide Design and Experimental Validation of Histone Methyltransferase Inhibitors

Histones are small proteins critical to the efficient packaging of DNA in the nucleus. DNA–protein complexes, known as nucleosomes, are formed when the DNA winds itself around the surface of the histones. The methylation of histone residues by enhancer of zeste homolog 2 (EZH2) maintains gene repres...

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Detalles Bibliográficos
Autores principales:	Smadbeck, James, Peterson, Meghan B., Zee, Barry M., Garapaty, Shivani, Mago, Aashna, Lee, Christina, Giannis, Athanassios, Trojer, Patrick, Garcia, Benjamin A., Floudas, Christodoulos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938834/ https://www.ncbi.nlm.nih.gov/pubmed/24587223 http://dx.doi.org/10.1371/journal.pone.0090095

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