Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()

BACKGROUND: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS: Bas...

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Detalles Bibliográficos
Autores principales: Delaunay, Jacques, Mazur, Grzegorz, Minden, Mark, Wierzbowska, Agnieszka, Jones, Mark M., Berrak, Erhan, Kantarjian, Hagop M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939385/
https://www.ncbi.nlm.nih.gov/pubmed/24596676
http://dx.doi.org/10.1016/j.lrr.2013.12.001
Descripción
Sumario:BACKGROUND: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. RESULTS: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. CONCLUSIONS: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.

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