Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()

BACKGROUND: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS: Bas...

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Autores principales: Delaunay, Jacques, Mazur, Grzegorz, Minden, Mark, Wierzbowska, Agnieszka, Jones, Mark M., Berrak, Erhan, Kantarjian, Hagop M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939385/
https://www.ncbi.nlm.nih.gov/pubmed/24596676
http://dx.doi.org/10.1016/j.lrr.2013.12.001
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author Delaunay, Jacques
Mazur, Grzegorz
Minden, Mark
Wierzbowska, Agnieszka
Jones, Mark M.
Berrak, Erhan
Kantarjian, Hagop M.
author_facet Delaunay, Jacques
Mazur, Grzegorz
Minden, Mark
Wierzbowska, Agnieszka
Jones, Mark M.
Berrak, Erhan
Kantarjian, Hagop M.
author_sort Delaunay, Jacques
collection PubMed
description BACKGROUND: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. RESULTS: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. CONCLUSIONS: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.
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spelling pubmed-39393852014-03-04 Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()() Delaunay, Jacques Mazur, Grzegorz Minden, Mark Wierzbowska, Agnieszka Jones, Mark M. Berrak, Erhan Kantarjian, Hagop M. Leuk Res Rep Article BACKGROUND: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. METHODS: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. RESULTS: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. CONCLUSIONS: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant. Elsevier 2013-12-27 /pmc/articles/PMC3939385/ /pubmed/24596676 http://dx.doi.org/10.1016/j.lrr.2013.12.001 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Delaunay, Jacques
Mazur, Grzegorz
Minden, Mark
Wierzbowska, Agnieszka
Jones, Mark M.
Berrak, Erhan
Kantarjian, Hagop M.
Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title_full Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title_fullStr Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title_full_unstemmed Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title_short Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
title_sort relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia()()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939385/
https://www.ncbi.nlm.nih.gov/pubmed/24596676
http://dx.doi.org/10.1016/j.lrr.2013.12.001
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