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Passive Immunization against HIV/AIDS by Antibody Gene Transfer

Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP...

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Autores principales: Yang, Lili, Wang, Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939464/
https://www.ncbi.nlm.nih.gov/pubmed/24473340
http://dx.doi.org/10.3390/v6020428
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author Yang, Lili
Wang, Pin
author_facet Yang, Lili
Wang, Pin
author_sort Yang, Lili
collection PubMed
description Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves passive immunization by viral vector-mediated delivery of genes encoding broadly neutralizing antibodies (bnAbs) for in vivo expression. Robust protection against virus infection was observed in preclinical settings when animals were given VIP to express monoclonal neutralizing antibodies. This unorthodox approach raises new promise for combating the ongoing global HIV pandemic. In this article, we survey the status of antibody gene transfer, review the revolutionary progress on isolation of extremely bnAbs, detail VIP experiments against HIV and its related virus conduced in humanized mice and macaque monkeys, and discuss the pros and cons of VIP and its opportunities and challenges towards clinical applications to control HIV/AIDS endemics.
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spelling pubmed-39394642014-03-03 Passive Immunization against HIV/AIDS by Antibody Gene Transfer Yang, Lili Wang, Pin Viruses Review Despite tremendous efforts over the course of many years, the quest for an effective HIV vaccine by the classical method of active immunization remains largely elusive. However, two recent studies in mice and macaques have now demonstrated a new strategy designated as Vectored ImmunoProphylaxis (VIP), which involves passive immunization by viral vector-mediated delivery of genes encoding broadly neutralizing antibodies (bnAbs) for in vivo expression. Robust protection against virus infection was observed in preclinical settings when animals were given VIP to express monoclonal neutralizing antibodies. This unorthodox approach raises new promise for combating the ongoing global HIV pandemic. In this article, we survey the status of antibody gene transfer, review the revolutionary progress on isolation of extremely bnAbs, detail VIP experiments against HIV and its related virus conduced in humanized mice and macaque monkeys, and discuss the pros and cons of VIP and its opportunities and challenges towards clinical applications to control HIV/AIDS endemics. MDPI 2014-01-27 /pmc/articles/PMC3939464/ /pubmed/24473340 http://dx.doi.org/10.3390/v6020428 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Yang, Lili
Wang, Pin
Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title_full Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title_fullStr Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title_full_unstemmed Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title_short Passive Immunization against HIV/AIDS by Antibody Gene Transfer
title_sort passive immunization against hiv/aids by antibody gene transfer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939464/
https://www.ncbi.nlm.nih.gov/pubmed/24473340
http://dx.doi.org/10.3390/v6020428
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