Cargando…

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

OBJECTIVE: Impaired amyloid clearance has been proposed to contribute to β-amyloid deposition in sporadic late-onset Alzheimer's disease (AD). Low density lipoprotein receptor-related protein 1 (LRP-1) is involved in the active outward transport of β-amyloid across the blood–brain barrier (BBB)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grimmer, Timo, Goldhardt, Oliver, Guo, Liang-Hao, Yousefi, Behrooz H., Förster, Stefan, Drzezga, Alexander, Sorg, Christian, Alexopoulos, Panagiotis, Förstl, Hans, Kurz, Alexander, Perneczky, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Regular Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939495/ https://www.ncbi.nlm.nih.gov/pubmed/24596678 http://dx.doi.org/10.1016/j.nicl.2014.01.016

Ejemplares similares

Cerebrospinal Fluid BACE1 Activity and Brain Amyloid Load in Alzheimer's Disease
por: Grimmer, Timo, et al.
Publicado: (2012)

Correction: (18)F-FIBT may expand PET for β-amyloid imaging in neurodegenerative diseases
por: Grimmer, Timo, et al.
Publicado: (2018)

Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease
por: Myers, Nicholas, et al.
Publicado: (2014)

Progressively Disrupted Intrinsic Functional Connectivity of Basolateral Amygdala in Very Early Alzheimer’s Disease
por: Ortner, Marion, et al.
Publicado: (2016)

Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PET
por: Goldhardt, Oliver, et al.
Publicado: (2019)

Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer’s disease
por: Ortner, Marion, et al.
Publicado: (2019)

Cerebrospinal fluid biomarkers for Alzheimer’s disease: the role of apolipoprotein E genotype, age, and sex
por: Mehrabian, Shima, et al.
Publicado: (2015)

Correction to: Amyloid PET, FDG-PET or MRI? - the power of different imaging biomarkers to detect progression of early Alzheimer’s disease
por: Ortner, Marion, et al.
Publicado: (2020)

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice
por: Yousefi, Behrooz H, et al.
Publicado: (2015)

Gaussian Mixture Models and Model Selection for [18F] Fluorodeoxyglucose Positron Emission Tomography Classification in Alzheimer’s Disease
por: Li, Rui, et al.
Publicado: (2015)

Prediction of Alzheimer's disease using individual structural connectivity networks
por: Shao, Junming, et al.
Publicado: (2012)

Impaired Cross-Modal Inhibition in Alzheimer Disease
por: Drzezga, Alexander, et al.
Publicado: (2005)

Decreased Vascular Pulsatility in Alzheimer’s Disease Dementia Measured by Transcranial Color-Coded Duplex Sonography
por: Ortner, Marion, et al.
Publicado: (2019)

Soluble amyloid precursor protein β as blood-based biomarker of Alzheimer's disease
por: Perneczky, R, et al.
Publicado: (2013)

Increased Intrinsic Brain Activity in the Striatum Reflects Symptom Dimensions in Schizophrenia
por: Sorg, Christian, et al.
Publicado: (2013)

Regional Cerebral Associations Between Psychometric Tests and Imaging Biomarkers in Alzheimer’s Disease
por: Hedderich, Dennis M., et al.
Publicado: (2020)

Serum Concentrations of Cholinesterase Inhibitors in Patients With Alzheimer’s Dementia Are Frequently Below the Recommended Levels
por: Ortner, Marion, et al.
Publicado: (2020)

Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study
por: Maleki Balajoo, Somayeh, et al.
Publicado: (2022)

Multicenter stability of resting state fMRI in the detection of Alzheimer's disease and amnestic MCI
por: Teipel, Stefan J., et al.
Publicado: (2017)

Elecsys Cerebrospinal Fluid Immunoassays Accurately Detect Alzheimer’s Disease Regardless of Concomitant Small Vessel Disease
por: Ortner, Marion, et al.
Publicado: (2023)

Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease
por: Alexopoulos, Panagiotis, et al.
Publicado: (2016)

Volume of interest-based [(18)F]fluorodeoxyglucose PET discriminates MCI converting to Alzheimer's disease from healthy controls. A European Alzheimer's Disease Consortium (EADC) study
por: Pagani, M., et al.
Publicado: (2014)

A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease
por: Nordberg, Agneta, et al.
Publicado: (2012)

Which medical and social decision topics are important after early diagnosis of Alzheimer’s Disease from the perspectives of people with Alzheimer’s Disease, spouses and professionals?
por: Bronner, Katharina, et al.
Publicado: (2016)

Cerebrospinal fluid lactate levels along the Alzheimer’s disease continuum and associations with blood-brain barrier integrity, age, cognition, and biomarkers
por: Zebhauser, Paul Theo, et al.
Publicado: (2022)

Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity
por: Duara, R., et al.
Publicado: (2019)

The cerebrospinal fluid biomarker ratio Aβ42/40 identifies amyloid positron emission tomography positivity better than Aβ42 alone in a heterogeneous memory clinic cohort
por: Amft, Michaela, et al.
Publicado: (2022)

Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer's disease
por: Jovanovic, Katarina, et al.
Publicado: (2013)

Neuroinflammation and amyloid deposition in the progression of mixed Alzheimer and vascular dementia
por: Ying, Chunwei, et al.
Publicado: (2023)

Unique regional patterns of amyloid burden predict progression to prodromal and clinical stages of Alzheimer's disease
por: Pfeil, Julia, et al.
Publicado: (2021)

Small-Animal PET Imaging of Amyloid-Beta Plaques with [(11)C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer's Disease
por: Manook, André, et al.
Publicado: (2012)

Impact of tau and amyloid burden on glucose metabolism in Alzheimer's disease
por: Bischof, Gérard N., et al.
Publicado: (2016)

Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's disease
por: Kerbler, Georg M, et al.
Publicado: (2014)

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease
por: Iaccarino, Leonardo, et al.
Publicado: (2017)

Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer’s Disease Stages
por: Pasquini, Lorenzo, et al.
Publicado: (2019)

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1
por: Ramanathan, Anita, et al.
Publicado: (2015)

Diagnosis of Alzheimer’s Disease with [18F]PET in Mild and Asymptomatic Stages
por: Drzezga, Alexander
Publicado: (2009)

LRP2 contributes to planar cell polarity-dependent coordination of motile cilia function
por: Bunatyan, Lena, et al.
Publicado: (2023)

Mathematical model and artificial intelligence for diagnosis of Alzheimer’s disease
por: Davodabadi, Afsaneh, et al.
Publicado: (2023)

Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer's Disease
por: McDonough, Ian M.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jr99pudv911tsfg42lj40huchp