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Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China
OBJECTIVES: Genetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB pathway gene polymorphisms and susceptibility of liver cancer. The aim of this study was to investigate...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939648/ https://www.ncbi.nlm.nih.gov/pubmed/24578542 http://dx.doi.org/10.1136/bmjopen-2013-004427 |
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author | Gao, Jing Xu, Hong-Li Gao, Shan Zhang, Wei Tan, Yu-Ting Rothman, Nat Purdue, Mark Gao, Yu-Tang Zheng, Wei Shu, Xiao-Ou Xiang, Yong-Bing |
author_facet | Gao, Jing Xu, Hong-Li Gao, Shan Zhang, Wei Tan, Yu-Ting Rothman, Nat Purdue, Mark Gao, Yu-Tang Zheng, Wei Shu, Xiao-Ou Xiang, Yong-Bing |
author_sort | Gao, Jing |
collection | PubMed |
description | OBJECTIVES: Genetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB pathway gene polymorphisms and susceptibility of liver cancer. The aim of this study was to investigate whether genetic variants of NFKB1 and NFKBIA were associated with risk of liver cancer in a Chinese population. DESIGN: The study was designed as a nested case–control study within two prospective cohorts (the Shanghai Women's Health Study, SWHS, 1996–2000 and the Shanghai Men's Health Study, SMHS, 2002–2006). SETTINGS: This population-based study was conducted in urban Shanghai, China. PARTICIPANTS: A total of 217 incident liver cancer cases diagnosed through 31 December 2009 and 427 healthy controls matched by sex, age at baseline (±2 years) and date (±30 days) of sample collection were included in the study. PRIMARY AND SECONDARY OUTCOME MEASURES: Genetic polymorphisms of NFKB1 and NFKBIA were determined blindly by TaqMan single-nucleotide polymorphism (SNP) genotyping assay. OR and its 95% CIs were estimated by an unconditional logistic regression model to measure the association between selected SNPs and the risk of liver cancer. RESULTS: After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26). Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model. No association was observed between NFKBIA variants and risk of live cancer. CONCLUSIONS: Our results suggest that genetic variants of NFKB1 influence liver cancer susceptibility in Chinese population, although replication in other studies is needed. |
format | Online Article Text |
id | pubmed-3939648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39396482014-03-03 Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China Gao, Jing Xu, Hong-Li Gao, Shan Zhang, Wei Tan, Yu-Ting Rothman, Nat Purdue, Mark Gao, Yu-Tang Zheng, Wei Shu, Xiao-Ou Xiang, Yong-Bing BMJ Open Epidemiology OBJECTIVES: Genetic variations of nuclear factor-κB (NF-κB) signalling pathway were found to be associated with inflammatory diseases and several malignancies. However, little is known about NF-κB pathway gene polymorphisms and susceptibility of liver cancer. The aim of this study was to investigate whether genetic variants of NFKB1 and NFKBIA were associated with risk of liver cancer in a Chinese population. DESIGN: The study was designed as a nested case–control study within two prospective cohorts (the Shanghai Women's Health Study, SWHS, 1996–2000 and the Shanghai Men's Health Study, SMHS, 2002–2006). SETTINGS: This population-based study was conducted in urban Shanghai, China. PARTICIPANTS: A total of 217 incident liver cancer cases diagnosed through 31 December 2009 and 427 healthy controls matched by sex, age at baseline (±2 years) and date (±30 days) of sample collection were included in the study. PRIMARY AND SECONDARY OUTCOME MEASURES: Genetic polymorphisms of NFKB1 and NFKBIA were determined blindly by TaqMan single-nucleotide polymorphism (SNP) genotyping assay. OR and its 95% CIs were estimated by an unconditional logistic regression model to measure the association between selected SNPs and the risk of liver cancer. RESULTS: After adjusted for potential confounding factors, rs28362491 ins/del or del/del genotypes were associated with higher risk of liver cancer with an adjusted OR 1.54 (95% CI 1.04 to 2.28). rs230496 AG and GG genotypes were also noted with higher risk of liver cancer with an adjusted OR 1.53 (95% CI 1.03 to 2.26). Haplotype analysis indicated that carriers of the NFKB1 GA and AA (rs230525-rs230530) haplotypes had higher risk of liver cancer under an additive model. No association was observed between NFKBIA variants and risk of live cancer. CONCLUSIONS: Our results suggest that genetic variants of NFKB1 influence liver cancer susceptibility in Chinese population, although replication in other studies is needed. BMJ Publishing Group 2014-02-27 /pmc/articles/PMC3939648/ /pubmed/24578542 http://dx.doi.org/10.1136/bmjopen-2013-004427 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Epidemiology Gao, Jing Xu, Hong-Li Gao, Shan Zhang, Wei Tan, Yu-Ting Rothman, Nat Purdue, Mark Gao, Yu-Tang Zheng, Wei Shu, Xiao-Ou Xiang, Yong-Bing Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title | Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title_full | Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title_fullStr | Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title_full_unstemmed | Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title_short | Genetic polymorphism of NFKB1 and NFKBIA genes and liver cancer risk: a nested case–control study in Shanghai, China |
title_sort | genetic polymorphism of nfkb1 and nfkbia genes and liver cancer risk: a nested case–control study in shanghai, china |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939648/ https://www.ncbi.nlm.nih.gov/pubmed/24578542 http://dx.doi.org/10.1136/bmjopen-2013-004427 |
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