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Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis

OBJECTIVES: For characterisation of mineral bone disease in chronic kidney disease (CKD), laboratory surrogates have been suggested. This observational should investigate the association of total and skeletal alkaline phosphatase (AP) with mortality of patients undergoing maintenance renal replaceme...

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Autores principales: Beige, Joachim, Wendt, Ralph, Girndt, Matthias, Queck, Karl-Heinz, Fiedler, Roman, Jehle, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939663/
https://www.ncbi.nlm.nih.gov/pubmed/24578540
http://dx.doi.org/10.1136/bmjopen-2013-004275
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author Beige, Joachim
Wendt, Ralph
Girndt, Matthias
Queck, Karl-Heinz
Fiedler, Roman
Jehle, Peter
author_facet Beige, Joachim
Wendt, Ralph
Girndt, Matthias
Queck, Karl-Heinz
Fiedler, Roman
Jehle, Peter
author_sort Beige, Joachim
collection PubMed
description OBJECTIVES: For characterisation of mineral bone disease in chronic kidney disease (CKD), laboratory surrogates have been suggested. This observational should investigate the association of total and skeletal alkaline phosphatase (AP) with mortality of patients undergoing maintenance renal replacement therapy. SETTING: Three renal outpatient centers in eastern-central Germany (secondary and tertiary care). PARTICIPANTS: Complete survival and laboratory datasets were available in 407 of 493 patients. Age and gender distribution was equivalent to a general population with end-stage CKD (CKD5D). Patients were included between 2008 and 2010 if at least 2 weeks of maintenance treatment were documented. PRIMARY OUTCOME MEASURES: Mortality was estimated by setting the end of dialysis date as event date. Events other than death (change to another centre, life-sustaining renal function or transplantation) were censored. RESULTS: The OR to die within follow-up for patients in the higher of two total AP strata was 2.70 (95% CI 1.76 to 4.15). In univariate Kaplan-Meier analysis, total AP had a strong association with all-cause mortality (LogRank=24.1, p<0.001). Mean total AP and individual lowest skeletal AP, but not mean skeletal AP entered step-wise Cox models for survival from dialysis start (χ(2)=22.4; p<0.001) after adjusting for age, Kt/V, diabetes and vintage. Mean values of skeletal, total AP and parathyroid hormone were 14.8±8.9 µg/L, 91.9±55.3 U/L and 188±164 ng/L, respectively. Skeletal and total AP were highly correlated (R=0.86; p<0.001). CONCLUSIONS: This unselected CKD5D population exhibited a clinical significant association of total AP with crude mortality and a stronger death risk association of total AP and individual lowest skeletal AP with crude mortality.
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spelling pubmed-39396632014-03-03 Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis Beige, Joachim Wendt, Ralph Girndt, Matthias Queck, Karl-Heinz Fiedler, Roman Jehle, Peter BMJ Open Renal Medicine OBJECTIVES: For characterisation of mineral bone disease in chronic kidney disease (CKD), laboratory surrogates have been suggested. This observational should investigate the association of total and skeletal alkaline phosphatase (AP) with mortality of patients undergoing maintenance renal replacement therapy. SETTING: Three renal outpatient centers in eastern-central Germany (secondary and tertiary care). PARTICIPANTS: Complete survival and laboratory datasets were available in 407 of 493 patients. Age and gender distribution was equivalent to a general population with end-stage CKD (CKD5D). Patients were included between 2008 and 2010 if at least 2 weeks of maintenance treatment were documented. PRIMARY OUTCOME MEASURES: Mortality was estimated by setting the end of dialysis date as event date. Events other than death (change to another centre, life-sustaining renal function or transplantation) were censored. RESULTS: The OR to die within follow-up for patients in the higher of two total AP strata was 2.70 (95% CI 1.76 to 4.15). In univariate Kaplan-Meier analysis, total AP had a strong association with all-cause mortality (LogRank=24.1, p<0.001). Mean total AP and individual lowest skeletal AP, but not mean skeletal AP entered step-wise Cox models for survival from dialysis start (χ(2)=22.4; p<0.001) after adjusting for age, Kt/V, diabetes and vintage. Mean values of skeletal, total AP and parathyroid hormone were 14.8±8.9 µg/L, 91.9±55.3 U/L and 188±164 ng/L, respectively. Skeletal and total AP were highly correlated (R=0.86; p<0.001). CONCLUSIONS: This unselected CKD5D population exhibited a clinical significant association of total AP with crude mortality and a stronger death risk association of total AP and individual lowest skeletal AP with crude mortality. BMJ Publishing Group 2014-02-26 /pmc/articles/PMC3939663/ /pubmed/24578540 http://dx.doi.org/10.1136/bmjopen-2013-004275 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Renal Medicine
Beige, Joachim
Wendt, Ralph
Girndt, Matthias
Queck, Karl-Heinz
Fiedler, Roman
Jehle, Peter
Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title_full Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title_fullStr Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title_full_unstemmed Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title_short Association of serum alkaline phosphatase with mortality in non-selected European patients with CKD5D: an observational, three-centre survival analysis
title_sort association of serum alkaline phosphatase with mortality in non-selected european patients with ckd5d: an observational, three-centre survival analysis
topic Renal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939663/
https://www.ncbi.nlm.nih.gov/pubmed/24578540
http://dx.doi.org/10.1136/bmjopen-2013-004275
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