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Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for melioidosis (MERTH): a multicentre, double-blind, non-inferiority, randomised controlled trial

BACKGROUND: Melioidosis, an infectious disease caused by the Gram-negative bacillus Burkholderia pseudomallei, is difficult to cure. Antimicrobial treatment comprises intravenous drugs for at least 10 days, followed by oral drugs for at least 12 weeks. The standard oral regimen based on trial eviden...

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Detalles Bibliográficos
Autores principales: Chetchotisakd, Ploenchan, Chierakul, Wirongrong, Chaowagul, Wipada, Anunnatsiri, Siriluck, Phimda, Kriangsak, Mootsikapun, Piroon, Chaisuksant, Seksan, Pilaikul, Jiraporn, Thinkhamrop, Bandit, Phiphitaporn, Sunchai, Susaengrat, Wattanachai, Toondee, Chalongchai, Wongrattanacheewin, Surasakdi, Wuthiekanun, Vanaporn, Chantratita, Narisara, Thaipadungpanit, Janjira, Day, Nicholas P, Limmathurotsakul, Direk, Peacock, Sharon J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939931/
https://www.ncbi.nlm.nih.gov/pubmed/24284287
http://dx.doi.org/10.1016/S0140-6736(13)61951-0