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Cell-Type-Specific Effects of RNase L on Viral Induction of Beta Interferon

The interferon (IFN)-inducible antiviral state is mediated in part by the 2′,5′-oligoadenylate (2-5A) synthetase (OAS)/RNase L system. 2-5A, produced from ATP by OAS proteins in response to viral double-stranded RNA, binds to and activates RNase L. RNase L restricts viral infections by degrading vir...

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Detalles Bibliográficos
Autores principales:	Banerjee, Shuvojit, Chakrabarti, Arindam, Jha, Babal Kant, Weiss, Susan R., Silverman, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2014
Materias:	Observation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940032/ https://www.ncbi.nlm.nih.gov/pubmed/24570368 http://dx.doi.org/10.1128/mBio.00856-14

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