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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters

Precise homoeostasis of the intracellular concentration of Cl(−) is achieved via the co-ordinated activities of the Cl(−) influx and efflux. We demonstrate that the WNK (WNK lysine-deficient protein kinase)-activated SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive k...

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Detalles Bibliográficos
Autores principales:	delos Heros, Paola, Alessi, Dario R., Gourlay, Robert, Campbell, David G., Deak, Maria, Macartney, Thomas J., Kahle, Kristopher T., Zhang, Jinwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940040/ https://www.ncbi.nlm.nih.gov/pubmed/24393035 http://dx.doi.org/10.1042/BJ20131478

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