Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor–ligand complex

Sortilin is a type I membrane glycoprotein belonging to the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors and is most abundantly expressed in the central nervous system. Sortilin has emerged as a key player in the regulation of neuronal viability and has been implicated as...

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Detalles Bibliográficos
Autores principales: Andersen, Jacob Lauwring, Schrøder, Tenna Juul, Christensen, Søren, Strandbygård, Dorthe, Pallesen, Lone Tjener, García-Alai, Maria Marta, Lindberg, Samsa, Langgård, Morten, Eskildsen, Jørgen Calí, David, Laurent, Tagmose, Lena, Simonsen, Klaus Baek, Maltas, Philip James, Rønn, Lars Christian Biilmann, de Jong, Inge E. M., Malik, Ibrahim John, Egebjerg, Jan, Karlsson, Jens-Jacob, Uppalanchi, Srinivas, Sakumudi, Durga Rao, Eradi, Pradheep, Watson, Steven P., Thirup, Søren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940197/
https://www.ncbi.nlm.nih.gov/pubmed/24531479
http://dx.doi.org/10.1107/S1399004713030149

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