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The structures of the kinase domain and UBA domain of MPK38 suggest the activation mechanism for kinase activity

Murine protein serine/threonine kinase 38 (MPK38) is the murine orthologue of human maternal embryonic leucine-zipper kinase (MELK), which belongs to the SNF1/AMPK family. MELK is considered to be a promising drug target for anticancer therapy because overexpression and hyperactivation of MELK is co...

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Detalles Bibliográficos
Autores principales:	Cho, Yong-Soon, Yoo, Jiho, Park, Soomin, Cho, Hyun-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940201/ https://www.ncbi.nlm.nih.gov/pubmed/24531485 http://dx.doi.org/10.1107/S1399004713027806

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