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Design, Synthesis, and Characterization of α-Ketoheterocycles That Additionally Target the Cytosolic Port Cys269 of Fatty Acid Amide Hydrolase

[Image: see text] A series of α-ketooxazoles incorporating electrophiles at the C5 position of the pyridyl ring of 2 (OL-135) and related compounds were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH) that additionally target the cytosolic port Cys269. From this series, a su...

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Detalles Bibliográficos
Autores principales:	Otrubova, Katerina, Cravatt, Benjamin F., Boger, Dale L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940414/ https://www.ncbi.nlm.nih.gov/pubmed/24456116 http://dx.doi.org/10.1021/jm401820q

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