Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference

Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a significant obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spin...

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Autores principales: Munoz-Cuevas, Francisco Javier, Athilingam, Jegath, Piscopo, Denise, Wilbrecht, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940437/
https://www.ncbi.nlm.nih.gov/pubmed/23974707
http://dx.doi.org/10.1038/nn.3498
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author Munoz-Cuevas, Francisco Javier
Athilingam, Jegath
Piscopo, Denise
Wilbrecht, Linda
author_facet Munoz-Cuevas, Francisco Javier
Athilingam, Jegath
Piscopo, Denise
Wilbrecht, Linda
author_sort Munoz-Cuevas, Francisco Javier
collection PubMed
description Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a significant obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest new persistent spine formation in the frontal cortex may play a role in stimulant-related learning driving appetitive behavior.
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spelling pubmed-39404372014-04-01 Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference Munoz-Cuevas, Francisco Javier Athilingam, Jegath Piscopo, Denise Wilbrecht, Linda Nat Neurosci Article Contextual cues associated with previous drug exposure can trigger drug craving and seeking, and form a significant obstacle in substance use recovery. Using in vivo imaging in mice, we found that cocaine administration induced a rapid increase in the formation and accumulation of new dendritic spines, and that measures of new persistent spine gain correlated with cocaine conditioned place preference. Our data suggest new persistent spine formation in the frontal cortex may play a role in stimulant-related learning driving appetitive behavior. 2013-08-25 2013-10 /pmc/articles/PMC3940437/ /pubmed/23974707 http://dx.doi.org/10.1038/nn.3498 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Munoz-Cuevas, Francisco Javier
Athilingam, Jegath
Piscopo, Denise
Wilbrecht, Linda
Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title_full Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title_fullStr Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title_full_unstemmed Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title_short Cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
title_sort cocaine-induced structural plasticity in frontal cortex correlates with conditioned place preference
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940437/
https://www.ncbi.nlm.nih.gov/pubmed/23974707
http://dx.doi.org/10.1038/nn.3498
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AT wilbrechtlinda cocaineinducedstructuralplasticityinfrontalcortexcorrelateswithconditionedplacepreference

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