Inhibition of Gsk3β activity improves β-cell function in c-Kit(Wv/+) male mice

Previous studies have shown that the stem cell marker, c-Kit, is involved in glucose homeostasis. We recently reported that c-Kit(Wv/+) male mice displayed onset of diabetes at 8 weeks of age; however, the mechanisms by which c-Kit regulates β-cell proliferation and function are unknown. The purpose...

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Detalles Bibliográficos
Autores principales: Feng, Zhi-Chao, Donnelly, Lisa, Li, Jinming, Krishnamurthy, Mansa, Riopel, Matthew, Wang, Rennian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940483/
https://www.ncbi.nlm.nih.gov/pubmed/22249311
http://dx.doi.org/10.1038/labinvest.2011.200