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Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments()
The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and mea...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940594/ https://www.ncbi.nlm.nih.gov/pubmed/25756000 http://dx.doi.org/10.1016/j.rinphs.2013.10.002 |
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author | Inoue, Yutaka Maeda, Rikimaru Furuya, Kayoko Isamu, Murata Masayuki, Kimura Kanamoto, Ikuo |
author_facet | Inoue, Yutaka Maeda, Rikimaru Furuya, Kayoko Isamu, Murata Masayuki, Kimura Kanamoto, Ikuo |
author_sort | Inoue, Yutaka |
collection | PubMed |
description | The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments were used: TA-A, a brand-name preparation, and TA-B and TA-C, two generics. The sensory test revealed significant differences between TA-A and TA-B and TA-C in terms of cohesiveness and spreadability. Significant differences between TA-A and TA-C and between TA-B and TA-C in terms of feel were noted. Microscopic examination revealed that TA-C had good dispersibility while TA-A and TA-B produced crystallization. NIR spectroscopy revealed differences in absorption spectra attributed to oil and water content in TAA, TA-B, and TA-C. Measurement of water content indicated water content of 0.06 ± 0.02% for TA-A, 0.08 ± 0.08% for TA-B, and 36.7 ± 1.19% for TA-C. Assessment of viscoelasticity indicated that stress decreased for all 3 ointments at 35 °C compared to that at 25 °C. TA-A and TA-B were found to have a higher percent decrease in stress than was TA-C. These findings indicate that differences in the types and content of additives caused differences in the physicochemical properties of individual ointments. In addition, differences in physicochemical properties presumably resulted in the close correlation between cohesiveness and spreadability in the sensory test. |
format | Online Article Text |
id | pubmed-3940594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-39405942015-03-09 Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() Inoue, Yutaka Maeda, Rikimaru Furuya, Kayoko Isamu, Murata Masayuki, Kimura Kanamoto, Ikuo Results Pharma Sci Article The purpose of this study was to examine the physicochemical properties of TA ointments and conduct a human sensory test to assess the properties of those ointments. Physicochemical assessment was done via near-infrared (NIR) absorption spectroscopy, measurement of water content, microscopy, and measurement of viscoelasticity. The human sensory test examined 5 aspects (texture, cohesiveness, spreadability, smell, and feel). Three TA ointments were used: TA-A, a brand-name preparation, and TA-B and TA-C, two generics. The sensory test revealed significant differences between TA-A and TA-B and TA-C in terms of cohesiveness and spreadability. Significant differences between TA-A and TA-C and between TA-B and TA-C in terms of feel were noted. Microscopic examination revealed that TA-C had good dispersibility while TA-A and TA-B produced crystallization. NIR spectroscopy revealed differences in absorption spectra attributed to oil and water content in TAA, TA-B, and TA-C. Measurement of water content indicated water content of 0.06 ± 0.02% for TA-A, 0.08 ± 0.08% for TA-B, and 36.7 ± 1.19% for TA-C. Assessment of viscoelasticity indicated that stress decreased for all 3 ointments at 35 °C compared to that at 25 °C. TA-A and TA-B were found to have a higher percent decrease in stress than was TA-C. These findings indicate that differences in the types and content of additives caused differences in the physicochemical properties of individual ointments. In addition, differences in physicochemical properties presumably resulted in the close correlation between cohesiveness and spreadability in the sensory test. Elsevier 2013-11-06 /pmc/articles/PMC3940594/ /pubmed/25756000 http://dx.doi.org/10.1016/j.rinphs.2013.10.002 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-No Derivative Works License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Article Inoue, Yutaka Maeda, Rikimaru Furuya, Kayoko Isamu, Murata Masayuki, Kimura Kanamoto, Ikuo Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title | Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title_full | Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title_fullStr | Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title_full_unstemmed | Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title_short | Relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
title_sort | relationship between the usability and physicochemical properties of triamcinolone acetonide ointments() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940594/ https://www.ncbi.nlm.nih.gov/pubmed/25756000 http://dx.doi.org/10.1016/j.rinphs.2013.10.002 |
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