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Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding

BACKGROUND: We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a...

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Detalles Bibliográficos
Autores principales:	Vistnes, Maria, Aronsen, Jan Magnus, Lunde, Ida G., Sjaastad, Ivar, Carlson, Cathrine R., Christensen, Geir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940660/ https://www.ncbi.nlm.nih.gov/pubmed/24595230 http://dx.doi.org/10.1371/journal.pone.0089621

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