Effect of Arginase Inhibition on Pulmonary L-Arginine Metabolism in Murine Pseudomonas Pneumonia

RATIONALE: Infection of the lung with Pseudomonas aeruginosa results in upregulation of nitric oxide synthases (NOS) and arginase expression, and both enzymes compete for L-arginine as substrate. Nitric oxide (NO) production may be regulated by arginase as it controls L-arginine availability for NOS...

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Detalles Bibliográficos
Autores principales: Mehl, Anne, Ghorbani, Peyman, Douda, David, Huang, Hailu, Palaniyar, Nades, Ratjen, Felix, Grasemann, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940779/
https://www.ncbi.nlm.nih.gov/pubmed/24595185
http://dx.doi.org/10.1371/journal.pone.0090232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940779/
https://www.ncbi.nlm.nih.gov/pubmed/24595185
http://dx.doi.org/10.1371/journal.pone.0090232

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