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Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects
Irisin is assumed to be a relevant link between muscle and weight maintenance as well as to mediate exercise benefits on health. The aim of this study was to assess the possible associations between irisin levels and glucose homeostasis in obese subjects with metabolic syndrome (MetS) following an e...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940831/ https://www.ncbi.nlm.nih.gov/pubmed/24567125 http://dx.doi.org/10.1038/nutd.2014.7 |
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author | Lopez-Legarrea, P de la Iglesia, R Crujeiras, A B Pardo, M Casanueva, F F Zulet, M A Martinez, J A |
author_facet | Lopez-Legarrea, P de la Iglesia, R Crujeiras, A B Pardo, M Casanueva, F F Zulet, M A Martinez, J A |
author_sort | Lopez-Legarrea, P |
collection | PubMed |
description | Irisin is assumed to be a relevant link between muscle and weight maintenance as well as to mediate exercise benefits on health. The aim of this study was to assess the possible associations between irisin levels and glucose homeostasis in obese subjects with metabolic syndrome (MetS) following an energy-restricted treatment. Ninety-six adults with excessive body weight and MetS features underwent a hypocaloric dietary pattern for 8 weeks, within the RESMENA randomized controlled trial (www.clinicaltrials.gov; NCT01087086). After the intervention, dietary restriction significantly reduced body weight and evidenced a dietary-induced decrease in circulating levels of irisin in parallel with improvements on glucose homeostasis markers. Interestingly, participants with higher irisin values at baseline (above the median) showed a greater reduction on glucose (P=0.022) and insulin (P=0.021) concentrations as well as on the homeostasis model assessment index (P=0.008) and triglycerides (P=0.006) after the dietary intervention, compared with those presenting low-irisin baseline values (below the median). Interestingly, a positive correlation between irisin and carbohydrate intake was found at the end of the experimental period. In conclusion, irisin appears to be involved in glucose metabolism regulation after a dietary-induced weight loss. |
format | Online Article Text |
id | pubmed-3940831 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-39408312014-03-04 Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects Lopez-Legarrea, P de la Iglesia, R Crujeiras, A B Pardo, M Casanueva, F F Zulet, M A Martinez, J A Nutr Diabetes Short Communication Irisin is assumed to be a relevant link between muscle and weight maintenance as well as to mediate exercise benefits on health. The aim of this study was to assess the possible associations between irisin levels and glucose homeostasis in obese subjects with metabolic syndrome (MetS) following an energy-restricted treatment. Ninety-six adults with excessive body weight and MetS features underwent a hypocaloric dietary pattern for 8 weeks, within the RESMENA randomized controlled trial (www.clinicaltrials.gov; NCT01087086). After the intervention, dietary restriction significantly reduced body weight and evidenced a dietary-induced decrease in circulating levels of irisin in parallel with improvements on glucose homeostasis markers. Interestingly, participants with higher irisin values at baseline (above the median) showed a greater reduction on glucose (P=0.022) and insulin (P=0.021) concentrations as well as on the homeostasis model assessment index (P=0.008) and triglycerides (P=0.006) after the dietary intervention, compared with those presenting low-irisin baseline values (below the median). Interestingly, a positive correlation between irisin and carbohydrate intake was found at the end of the experimental period. In conclusion, irisin appears to be involved in glucose metabolism regulation after a dietary-induced weight loss. Nature Publishing Group 2014-02 2014-02-24 /pmc/articles/PMC3940831/ /pubmed/24567125 http://dx.doi.org/10.1038/nutd.2014.7 Text en Copyright © 2014 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Short Communication Lopez-Legarrea, P de la Iglesia, R Crujeiras, A B Pardo, M Casanueva, F F Zulet, M A Martinez, J A Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title | Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title_full | Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title_fullStr | Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title_full_unstemmed | Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title_short | Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
title_sort | higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940831/ https://www.ncbi.nlm.nih.gov/pubmed/24567125 http://dx.doi.org/10.1038/nutd.2014.7 |
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