Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2

Previous studies have shown that pharmacologic inhibition of poly (ADP-ribose) polymerase (PARP), a nuclear protein that is crucial in signaling single-strand DNA breaks, is synthetically lethal to cancer cells from patients with genetic deficiency in the DNA repair proteins BRCA1 and BRCA2. Herein,...

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Detalles Bibliográficos
Autores principales: Arbini, A A, Guerra, F, Greco, M, Marra, E, Gandee, L, Xiao, G, Lotan, Y, Gasparre, G, Hsieh, J-T, Moro, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940862/
https://www.ncbi.nlm.nih.gov/pubmed/24336406
http://dx.doi.org/10.1038/oncsis.2013.45

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