ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin

A hallmark of Huntington’s disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of translation initiation factor eIF2α, a stress-ind...

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Detalles Bibliográficos
Autores principales: Leitman, Julia, Barak, Boaz, Benyair, Ron, Shenkman, Marina, Ashery, Uri, Hartl, F. Ulrich, Lederkremer, Gerardo Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940916/
https://www.ncbi.nlm.nih.gov/pubmed/24594939
http://dx.doi.org/10.1371/journal.pone.0090803

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