The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein

The redox-dependent inhibition of thioredoxin (TRX) by thioredoxin-interacting protein (TXNIP) plays a pivotal role in various cancers and metabolic syndromes. However, the molecular mechanism of this regulation is largely unknown. Here, we present the crystal structure of the TRX–TXNIP complex and...

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Detalles Bibliográficos
Autores principales: Hwang, Jungwon, Suh, Hyun-Woo, Jeon, Young Ho, Hwang, Eunha, Nguyen, Loi T., Yeom, Jeonghun, Lee, Seung-Goo, Lee, Cheolju, Kim, Kyung Jin, Kang, Beom Sik, Jeong, Jin-Ok, Oh, Tae-Kwang, Choi, Inpyo, Lee, Jie-Oh, Kim, Myung Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941024/
https://www.ncbi.nlm.nih.gov/pubmed/24389582
http://dx.doi.org/10.1038/ncomms3958

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