Protein tagging reveals new insights into signaling in flagella

In this issue, Oda et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201312014) use mutant analysis, protein tagging, and cryoelectron tomography to determine the detailed location of components in flagellar radial spokes—a complex of proteins that connect the peripheral microtubule doublets...

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Detalles Bibliográficos
Autor principal: Ishikawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941048/
https://www.ncbi.nlm.nih.gov/pubmed/24590169
http://dx.doi.org/10.1083/jcb.201401142
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author Ishikawa, Takashi
author_facet Ishikawa, Takashi
author_sort Ishikawa, Takashi
collection PubMed
description In this issue, Oda et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201312014) use mutant analysis, protein tagging, and cryoelectron tomography to determine the detailed location of components in flagellar radial spokes—a complex of proteins that connect the peripheral microtubule doublets to the central pair. Remarkably, this approach revealed an interaction between radial spokes and the central pair based on geometry rather than a specific signaling mechanism, highlighting the importance of studying a system in three dimensions.
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spelling pubmed-39410482014-09-03 Protein tagging reveals new insights into signaling in flagella Ishikawa, Takashi J Cell Biol Reviews In this issue, Oda et al. (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201312014) use mutant analysis, protein tagging, and cryoelectron tomography to determine the detailed location of components in flagellar radial spokes—a complex of proteins that connect the peripheral microtubule doublets to the central pair. Remarkably, this approach revealed an interaction between radial spokes and the central pair based on geometry rather than a specific signaling mechanism, highlighting the importance of studying a system in three dimensions. The Rockefeller University Press 2014-03-03 /pmc/articles/PMC3941048/ /pubmed/24590169 http://dx.doi.org/10.1083/jcb.201401142 Text en © 2014 Ishikawa This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Reviews
Ishikawa, Takashi
Protein tagging reveals new insights into signaling in flagella
title Protein tagging reveals new insights into signaling in flagella
title_full Protein tagging reveals new insights into signaling in flagella
title_fullStr Protein tagging reveals new insights into signaling in flagella
title_full_unstemmed Protein tagging reveals new insights into signaling in flagella
title_short Protein tagging reveals new insights into signaling in flagella
title_sort protein tagging reveals new insights into signaling in flagella
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941048/
https://www.ncbi.nlm.nih.gov/pubmed/24590169
http://dx.doi.org/10.1083/jcb.201401142
work_keys_str_mv AT ishikawatakashi proteintaggingrevealsnewinsightsintosignalinginflagella

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