A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint

Recruitment of Mad1–Mad2 complexes to unattached kinetochores is a central event in spindle checkpoint signaling. Despite its importance, the mechanism that recruits Mad1–Mad2 to kinetochores is unclear. In this paper, we show that MAD-1 interacts with BUB-1 in Caenorhabditis elegans. Mutagenesis id...

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Detalles Bibliográficos
Autores principales: Moyle, Mark W., Kim, Taekyung, Hattersley, Neil, Espeut, Julien, Cheerambathur, Dhanya K., Oegema, Karen, Desai, Arshad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941058/
https://www.ncbi.nlm.nih.gov/pubmed/24567362
http://dx.doi.org/10.1083/jcb.201311015

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