Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

Despite the well-documented clinical significance of the Warburg effect, it remains unclear how the aggressive glycolytic rates of tumor cells might contribute to other hallmarks of cancer, such as bypass of senescence. Here, we report that, during oncogene- or DNA damage–induced senescence, Pak1-me...

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Detalles Bibliográficos
Autores principales: Mikawa, Takumi, Maruyama, Takeshi, Okamoto, Koji, Nakagama, Hitoshi, Lleonart, Matilde E., Tsusaka, Takeshi, Hori, Kousuke, Murakami, Itsuo, Izumi, Taisuke, Takaori-Kondo, Akifumi, Yokode, Masayuki, Peters, Gordon, Beach, David, Kondoh, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941061/
https://www.ncbi.nlm.nih.gov/pubmed/24567357
http://dx.doi.org/10.1083/jcb.201306149

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