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Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population

Human hepatitis E virus (HHEV) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclin...

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Autor principal: Echevarría, José-Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941225/
https://www.ncbi.nlm.nih.gov/pubmed/24672733
http://dx.doi.org/10.1155/2014/481016
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author Echevarría, José-Manuel
author_facet Echevarría, José-Manuel
author_sort Echevarría, José-Manuel
collection PubMed
description Human hepatitis E virus (HHEV) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclinical, unrecognized infections. The overall prevalence of antibody to HHEV is high in most of the former areas and low in most of the later ones, but wide regional differences have been recorded in both cases. “Hot spots” of HHEV infection would exist for both types of strains in particular regions or among particular populations of the world. Studies on pork derivatives, shellfish bivalves, and vegetables for HHEV contamination at the sale point need to be extended for evaluating the impact of the agent on food safety, and the meaning of the finding of HHEV genotype 1 genomes in urban sewage from developed countries should be established through active surveillance. Consensus about technical issues in regard to anti-HEV testing would improve the knowledge of the HHEV epidemiology. Studies in particular regions and populations, and introduction of molecular diagnosis in the clinical setting as a routine tool, would also be required.
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spelling pubmed-39412252014-03-26 Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population Echevarría, José-Manuel Scientifica (Cairo) Review Article Human hepatitis E virus (HHEV) spreads early in life among the population in areas endemic for genotype 1 and infects mainly adults in areas endemic for genotype 3, where it would be responsible for about 10% of cases of suspected acute viral hepatitis of unknown etiology and for a number of subclinical, unrecognized infections. The overall prevalence of antibody to HHEV is high in most of the former areas and low in most of the later ones, but wide regional differences have been recorded in both cases. “Hot spots” of HHEV infection would exist for both types of strains in particular regions or among particular populations of the world. Studies on pork derivatives, shellfish bivalves, and vegetables for HHEV contamination at the sale point need to be extended for evaluating the impact of the agent on food safety, and the meaning of the finding of HHEV genotype 1 genomes in urban sewage from developed countries should be established through active surveillance. Consensus about technical issues in regard to anti-HEV testing would improve the knowledge of the HHEV epidemiology. Studies in particular regions and populations, and introduction of molecular diagnosis in the clinical setting as a routine tool, would also be required. Hindawi Publishing Corporation 2014 2014-02-10 /pmc/articles/PMC3941225/ /pubmed/24672733 http://dx.doi.org/10.1155/2014/481016 Text en Copyright © 2014 José-Manuel Echevarría. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Echevarría, José-Manuel
Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title_full Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title_fullStr Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title_full_unstemmed Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title_short Light and Darkness: Prevalence of Hepatitis E Virus Infection among the General Population
title_sort light and darkness: prevalence of hepatitis e virus infection among the general population
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941225/
https://www.ncbi.nlm.nih.gov/pubmed/24672733
http://dx.doi.org/10.1155/2014/481016
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