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Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study
BACKGROUND: Diabetes mellitus and thyroid diseases frequently coexist. In order to evaluate how thyroid disorders interfere with glycemic control, we analysed insulin-treated type 2 diabetes patients with thyroid disease. METHODS: Diabetes patients (n = 1.957) were retrospectively investigated. We f...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941259/ https://www.ncbi.nlm.nih.gov/pubmed/24580798 http://dx.doi.org/10.1186/1756-6614-7-2 |
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author | Witting, Valerie Bergis, Dominik Sadet, Dilek Badenhoop, Klaus |
author_facet | Witting, Valerie Bergis, Dominik Sadet, Dilek Badenhoop, Klaus |
author_sort | Witting, Valerie |
collection | PubMed |
description | BACKGROUND: Diabetes mellitus and thyroid diseases frequently coexist. In order to evaluate how thyroid disorders interfere with glycemic control, we analysed insulin-treated type 2 diabetes patients with thyroid disease. METHODS: Diabetes patients (n = 1.957) were retrospectively investigated. We focused on type 2 diabetes patients who had been admitted for insulin-treatment and diagnosed thyroid diseases (n = 328). Patients were divided into three groups according to thyroid disease manifestation in relation to diabetes onset: prior to (group 1), same year (group 2) and thyroid disease following diabetes (group 3). RESULTS: Out of all diabetes patients 27.3% had a thyroid disorder with more women (62.2%) being affected (p < 0.001). Thyroid disease was predominantly diagnosed after diabetes onset. Patients with type 2 diabetes and prior appearance of thyroid disease required insulin therapy significantly earlier (median insulin-free period: 2.5 yrs; Q(1) = 0.0, Q(3) = 8.25) compared to patients who had thyroid dysfunction after diabetes onset (median insulin-free period: 8.0 yrs; Q(1) = 3.0, Q(3) = 12.0; p < 0.001). Age at diabetes onset correlated with insulin-free period (p < 0.001). CONCLUSIONS: Thyroid disease may be a marker of a distinct metabolic trait in type 2 diabetes potentially requiring earlier insulin treatment. |
format | Online Article Text |
id | pubmed-3941259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39412592014-03-05 Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study Witting, Valerie Bergis, Dominik Sadet, Dilek Badenhoop, Klaus Thyroid Res Research BACKGROUND: Diabetes mellitus and thyroid diseases frequently coexist. In order to evaluate how thyroid disorders interfere with glycemic control, we analysed insulin-treated type 2 diabetes patients with thyroid disease. METHODS: Diabetes patients (n = 1.957) were retrospectively investigated. We focused on type 2 diabetes patients who had been admitted for insulin-treatment and diagnosed thyroid diseases (n = 328). Patients were divided into three groups according to thyroid disease manifestation in relation to diabetes onset: prior to (group 1), same year (group 2) and thyroid disease following diabetes (group 3). RESULTS: Out of all diabetes patients 27.3% had a thyroid disorder with more women (62.2%) being affected (p < 0.001). Thyroid disease was predominantly diagnosed after diabetes onset. Patients with type 2 diabetes and prior appearance of thyroid disease required insulin therapy significantly earlier (median insulin-free period: 2.5 yrs; Q(1) = 0.0, Q(3) = 8.25) compared to patients who had thyroid dysfunction after diabetes onset (median insulin-free period: 8.0 yrs; Q(1) = 3.0, Q(3) = 12.0; p < 0.001). Age at diabetes onset correlated with insulin-free period (p < 0.001). CONCLUSIONS: Thyroid disease may be a marker of a distinct metabolic trait in type 2 diabetes potentially requiring earlier insulin treatment. BioMed Central 2014-03-01 /pmc/articles/PMC3941259/ /pubmed/24580798 http://dx.doi.org/10.1186/1756-6614-7-2 Text en Copyright © 2014 Witting et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Witting, Valerie Bergis, Dominik Sadet, Dilek Badenhoop, Klaus Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title | Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title_full | Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title_fullStr | Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title_full_unstemmed | Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title_short | Thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
title_sort | thyroid disease in insulin-treated patients with type 2 diabetes: a retrospective study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941259/ https://www.ncbi.nlm.nih.gov/pubmed/24580798 http://dx.doi.org/10.1186/1756-6614-7-2 |
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