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Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial

Background: Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits. Objective: To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART pro...

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Autores principales: Eftekhar, Maryam, Rahmani, Elham, Mohammadian, Farnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research and Clinical Center for Infertility 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941354/
https://www.ncbi.nlm.nih.gov/pubmed/24639738
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author Eftekhar, Maryam
Rahmani, Elham
Mohammadian, Farnaz
author_facet Eftekhar, Maryam
Rahmani, Elham
Mohammadian, Farnaz
author_sort Eftekhar, Maryam
collection PubMed
description Background: Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits. Objective: To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART protocols. Materials and Methods: In a prospective randomized study, one hundred women who underwent ART cycles were randomly divided into two groups. In group I, the patients received one single injection of 1.87 mg Triptorelin in previous mid-luteal phase. In group II, Decapeptyl 0.1 mg per day started from previous mid-luteal phase. Pregnancy outcome in in vitro fertilization (IVF) cycle was compared between two groups. Results: There were no statistically significant differences in the number of retrieved oocyte (p=0.545), fertilization (p=0.876), implantation (p=0.716) and pregnancy rate (p=0.727) between the two groups. Conclusion: There were not any advantages in IVF outcome between half-dose long-acting and short-acting GnRH agonist groups in ART cycle.
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spelling pubmed-39413542014-03-17 Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial Eftekhar, Maryam Rahmani, Elham Mohammadian, Farnaz Iran J Reprod Med Background: Gonadotrophin-releasing hormone (GnRH) agonist is used for controlling ovarian stimulation in assisted reproductive technology (ART) cycles which has some benefits. Objective: To compare the efficacy of two different formulations of GnRH agonist: short-acting and long-acting, for ART protocols. Materials and Methods: In a prospective randomized study, one hundred women who underwent ART cycles were randomly divided into two groups. In group I, the patients received one single injection of 1.87 mg Triptorelin in previous mid-luteal phase. In group II, Decapeptyl 0.1 mg per day started from previous mid-luteal phase. Pregnancy outcome in in vitro fertilization (IVF) cycle was compared between two groups. Results: There were no statistically significant differences in the number of retrieved oocyte (p=0.545), fertilization (p=0.876), implantation (p=0.716) and pregnancy rate (p=0.727) between the two groups. Conclusion: There were not any advantages in IVF outcome between half-dose long-acting and short-acting GnRH agonist groups in ART cycle. Research and Clinical Center for Infertility 2013-02 /pmc/articles/PMC3941354/ /pubmed/24639738 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Eftekhar, Maryam
Rahmani, Elham
Mohammadian, Farnaz
Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title_full Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title_fullStr Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title_full_unstemmed Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title_short Comparison of pregnancy outcome in half-dose Triptorelin and short-acting Decapeptyl in long protocol in ART cycles: A randomized clinical trial
title_sort comparison of pregnancy outcome in half-dose triptorelin and short-acting decapeptyl in long protocol in art cycles: a randomized clinical trial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941354/
https://www.ncbi.nlm.nih.gov/pubmed/24639738
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