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Oral Session 03: CNS Risk

Exposure to space radiation may have impacts on brain function, either during or following missions. It is most important to determine how low doses of protons and high-LET irradiation elicit changes in brain function. Within this framework, the role of oxidative stress should also be assessed, as w...

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Detalles Bibliográficos
Autores principales: Narici, Livio, Nelson, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941503/
http://dx.doi.org/10.1093/jrr/rrt207
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author Narici, Livio
Nelson, Gregory A.
author_facet Narici, Livio
Nelson, Gregory A.
author_sort Narici, Livio
collection PubMed
description Exposure to space radiation may have impacts on brain function, either during or following missions. It is most important to determine how low doses of protons and high-LET irradiation elicit changes in brain function. Within this framework, the role of oxidative stress should also be assessed, as well as other possible interaction mechanisms involving, e.g., genetic, environmental, and sex-dependent risk factors. The hippocampus is particularly susceptible to radiation. It plays an essential role in memory formation and consolidation and is one of the most investigated brain components for its responses to radiation. The hippocampus is also one of the first brain structures to be damaged in the pathogenesis of Alzheimer's disease, an important potential late impairment following irradiation. In ‘Section 3: CNS risk’, six papers have been presented focused on these issues. For details the reader is directed to the specific papers. Here a very short summary follows.
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spelling pubmed-39415032014-03-04 Oral Session 03: CNS Risk Narici, Livio Nelson, Gregory A. J Radiat Res Oral Session 03: CNS Risk Exposure to space radiation may have impacts on brain function, either during or following missions. It is most important to determine how low doses of protons and high-LET irradiation elicit changes in brain function. Within this framework, the role of oxidative stress should also be assessed, as well as other possible interaction mechanisms involving, e.g., genetic, environmental, and sex-dependent risk factors. The hippocampus is particularly susceptible to radiation. It plays an essential role in memory formation and consolidation and is one of the most investigated brain components for its responses to radiation. The hippocampus is also one of the first brain structures to be damaged in the pathogenesis of Alzheimer's disease, an important potential late impairment following irradiation. In ‘Section 3: CNS risk’, six papers have been presented focused on these issues. For details the reader is directed to the specific papers. Here a very short summary follows. Oxford University Press 2014-03 /pmc/articles/PMC3941503/ http://dx.doi.org/10.1093/jrr/rrt207 Text en © The Author 2014. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Oral Session 03: CNS Risk
Narici, Livio
Nelson, Gregory A.
Oral Session 03: CNS Risk
title Oral Session 03: CNS Risk
title_full Oral Session 03: CNS Risk
title_fullStr Oral Session 03: CNS Risk
title_full_unstemmed Oral Session 03: CNS Risk
title_short Oral Session 03: CNS Risk
title_sort oral session 03: cns risk
topic Oral Session 03: CNS Risk
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941503/
http://dx.doi.org/10.1093/jrr/rrt207
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