Cargando…

Aggregation of 53BP1 and XRCC1 in cancer stem cells and non-stem cancer cells post-targeted proton irradiation

Tumor cells often exist in different phenotypes with distinct properties. Ever-increasing evidence strongly supported the existence of the cancer stem cells (CSCs) and non-stem cancer cells (NSCCs) in various tumors. It is of fundamental importance to understand the properties of the phenotypes unde...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Gen, Konishi, Teruaki, Kobayashi, Alisa, Maeda, Takeshi, Uchihori, Yukio, Hei, Tom K., Wang, Yugang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Poster Session 01: DNA Damage and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941531/ http://dx.doi.org/10.1093/jrr/rrt156

Ejemplares similares

Session 1: DNA repair
por: Iliakis, George
Publicado: (2014)

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells
por: Eckelmann, Bradley J, et al.
Publicado: (2020)

Quantitative characteristics of clustered DNA damage in irradiated cells by heavy ion beams
por: Terato, Hiroaki, et al.
Publicado: (2014)

mBAND analysis of early and late damages in the chromosome of human lymphocytes after exposures to gamma rays and Fe ions
por: Yuasa-Sunagawa, Mayumi, et al.
Publicado: (2014)

Homologous recombination pathway may play a major role in high-LET radiation-induced DNA double-strand break repair
por: Gerelchuluun, Ariungerel, et al.
Publicado: (2014)

Chromatin differentiation of white blood cells decreases DSB damage induction, prevents functional assembly of repair foci, but has no influence on protrusion of heterochromatic DSBs into the low-dense chromatin
por: Falk, Martin, et al.
Publicado: (2014)

Primary and secondary clustering of DSB repair foci and repair kinetics compared for γ-rays, protons of different energies and high-LET (20)Ne ions
por: Falk, Martin, et al.
Publicado: (2014)

Dependence of the yields of AP sites and AP clusters produced in plasmid DNA on scavenging capacity and LET
por: Shiina, Takuya, et al.
Publicado: (2014)

Mutagenic joining of enzymatically induced DNA double-strand breaks, accompanied by persistent unrepaired DNA damage and a secretory protein phenotype, in HZE-exposed human cells
por: Li, Zhentian, et al.
Publicado: (2014)

A role for reactive oxygen species in the resolution of persistent genomic instability after exposure to radiation
por: Werner, Erica, et al.
Publicado: (2014)

Estimation of effects of space radiation using frozen mouse ES cells in ISS
por: Yoshida, K., et al.
Publicado: (2014)

Order effect of repair processes to clustered DNA damage
por: Shiraishi, Iyo, et al.
Publicado: (2014)

NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells
por: Li, Jianfeng, et al.
Publicado: (2021)

Multiple-low-dose therapy: effective killing of high-grade serous ovarian cancer cells with ATR and CHK1 inhibitors
por: Golder, Anya, et al.
Publicado: (2022)

CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination
por: Brown, Victoria E, et al.
Publicado: (2023)

Large-scale phenogenomic analysis of human cancers uncovers frequent alterations affecting SMC5/6 complex components in breast cancer
por: Roy, Shamayita, et al.
Publicado: (2023)

Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma
por: Benada, Jan, et al.
Publicado: (2023)

Defining the mutation signatures of DNA polymerase θ in cancer genomes
por: Hwang, Taejoo, et al.
Publicado: (2020)

EEPD1 promotes repair of oxidatively-stressed replication forks
por: Jaiswal, Aruna S, et al.
Publicado: (2023)

Ubiquitination-mediated degradation of TRDMT1 regulates homologous recombination and therapeutic response
por: Zhu, Xiaolan, et al.
Publicado: (2021)

Distinct roles of structure-specific endonucleases EEPD1 and Metnase in replication stress responses
por: Sharma, Neelam, et al.
Publicado: (2020)

The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
por: Safavi, Shiva, et al.
Publicado: (2020)

High-throughput screen to identify compounds that prevent or target telomere loss in human cancer cells
por: Wilson, Chris, et al.
Publicado: (2022)

Escape from G1 arrest during acute MEK inhibition drives the acquisition of drug resistance
por: Channathodiyil, Prasanna, et al.
Publicado: (2022)

Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and S(N)1 chemotherapeutic agents
por: Armijo, Amanda L, et al.
Publicado: (2023)

Specificity of cancer-related chromosomal translocations is linked to proximity after the DNA double-strand break and subsequent selection
por: Canoy, Reynand Jay, et al.
Publicado: (2023)

ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe
por: Heyza, Joshua R, et al.
Publicado: (2023)

Alkylation of nucleobases by 2-chloro-N,N-diethylethanamine hydrochloride (CDEAH) sensitizes PARP1-deficient tumors
por: Wie, Minwoo, et al.
Publicado: (2023)

Proteome dynamics analysis identifies functional roles of SDE2 and hypoxia in DNA damage response in prostate cancer cells
por: Luo, Ang, et al.
Publicado: (2020)

The DNA damage inducible lncRNA SCAT7 regulates genomic integrity and topoisomerase 1 turnover in lung adenocarcinoma
por: Statello, Luisa, et al.
Publicado: (2021)

The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells
por: Vickridge, Elise, et al.
Publicado: (2022)

Clinical and functional characterization of CXCR1/CXCR2 biology in the relapse and radiotherapy resistance of primary PTEN-deficient prostate carcinoma
por: Armstrong, Chris W D, et al.
Publicado: (2020)

Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer
por: Wiegmans, Adrian P, et al.
Publicado: (2021)

Intrinsic ATR signaling shapes DNA end resection and suppresses toxic DNA-PKcs signaling
por: Dibitetto, Diego, et al.
Publicado: (2020)

APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response
por: Conner, Kayla L, et al.
Publicado: (2020)

DDX5 resolves R-loops at DNA double-strand breaks to promote DNA repair and avoid chromosomal deletions
por: Yu, Zhenbao, et al.
Publicado: (2020)

Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells
por: Reed, Megan R, et al.
Publicado: (2021)

Tracking telomere fusions through crisis reveals conflict between DNA transcription and the DNA damage response
por: Liddiard, Kate, et al.
Publicado: (2021)

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency
por: Kumar, Rashmi J, et al.
Publicado: (2020)

The HelQ human DNA repair helicase utilizes a PWI-like domain for DNA loading through interaction with RPA, triggering DNA unwinding by the HelQ helicase core
por: Jenkins, Tabitha, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_orlu9isj50ijai3peqg60nm12f