Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells

BACKGROUND: mTOR, which can form mTOR Complex 1 (mTORC1) or mTOR Complex 2 (mTORC2) depending on its binding partners, is frequently deregulated in the pulmonary neoplastic conditions and interstitial lung diseases of the patients treated with rapalogs. In this study, we investigated the relationshi...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Eun Young, Kim, Arum, Kim, Se Kyu, Kim, Hyung Jung, Chang, Joon, Ahn, Chul Min, Chang, Yoon Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941688/
https://www.ncbi.nlm.nih.gov/pubmed/24571487
http://dx.doi.org/10.1186/1465-9921-15-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941688/
https://www.ncbi.nlm.nih.gov/pubmed/24571487
http://dx.doi.org/10.1186/1465-9921-15-26

Ejemplares similares