Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3β signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells

BACKGROUND: mTOR, which can form mTOR Complex 1 (mTORC1) or mTOR Complex 2 (mTORC2) depending on its binding partners, is frequently deregulated in the pulmonary neoplastic conditions and interstitial lung diseases of the patients treated with rapalogs. In this study, we investigated the relationshi...

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Detalles Bibliográficos
Autores principales: Kim, Eun Young, Kim, Arum, Kim, Se Kyu, Kim, Hyung Jung, Chang, Joon, Ahn, Chul Min, Chang, Yoon Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941688/
https://www.ncbi.nlm.nih.gov/pubmed/24571487
http://dx.doi.org/10.1186/1465-9921-15-26

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