Accelerating clinical development of HIV vaccine strategies: methodological challenges and considerations in constructing an optimised multi-arm phase I/II trial design

BACKGROUND: Many candidate vaccine strategies against human immunodeficiency virus (HIV) infection are under study, but their clinical development is lengthy and iterative. To accelerate HIV vaccine development optimised trial designs are needed. We propose a randomised multi-arm phase I/II design f...

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Detalles Bibliográficos
Autores principales: Richert, Laura, Doussau, Adélaïde, Lelièvre, Jean-Daniel, Arnold, Vincent, Rieux, Véronique, Bouakane, Amel, Lévy, Yves, Chêne, Geneviève, Thiébaut, Rodolphe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941694/
https://www.ncbi.nlm.nih.gov/pubmed/24571662
http://dx.doi.org/10.1186/1745-6215-15-68

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