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Physical and psychological long-term outcome after traumatic brain injury in children and adult patients

BACKGROUND: Several studies have indicated that younger age is associated with worse recovery after pediatric traumatic brain injury (TBI) compared to elder children. In order to verify this association between long-term outcome after moderate to severe TBI and patient’s age, direct comparison betwe...

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Autores principales: Andruszkow, Hagen, Deniz, Ezin, Urner, Julia, Probst, Christian, Grün, Orna, Lohse, Ralf, Frink, Michael, Krettek, Christian, Zeckey, Christian, Hildebrand, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941774/
https://www.ncbi.nlm.nih.gov/pubmed/24571742
http://dx.doi.org/10.1186/1477-7525-12-26
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author Andruszkow, Hagen
Deniz, Ezin
Urner, Julia
Probst, Christian
Grün, Orna
Lohse, Ralf
Frink, Michael
Krettek, Christian
Zeckey, Christian
Hildebrand, Frank
author_facet Andruszkow, Hagen
Deniz, Ezin
Urner, Julia
Probst, Christian
Grün, Orna
Lohse, Ralf
Frink, Michael
Krettek, Christian
Zeckey, Christian
Hildebrand, Frank
author_sort Andruszkow, Hagen
collection PubMed
description BACKGROUND: Several studies have indicated that younger age is associated with worse recovery after pediatric traumatic brain injury (TBI) compared to elder children. In order to verify this association between long-term outcome after moderate to severe TBI and patient’s age, direct comparison between different pediatric age groups as well as an adult population was performed. METHODS: This investigation represents a retrospective cohort study at a level I trauma center including patients with moderate to severe, isolated TBI with a minimum follow-up of 10 years. According to their age at time of injury, patients were divided in pre-school (0–7 years), school (8–17 years) and adult (18–65 years) patients. Physical examination and standardized questionnaire on physical and psychological aspects (Glasgow Outcome Scale, Barthel Index, Impact of Event Scale, Hospital Anxiety and Depression Scale, short form 12) were performed. RESULTS: 135 traumatized patients were included. Physical and psychological long-term outcome was associated with injury severity but not with patients’ age at time of injury. Outcome recovery measured by Glasgow Outcome Scale was demonstrated with best results for pre-school aged children (p = 0.009). According to the Hospital Anxiety and Depression Scale an increased incidence of anxiety (p = 0.010) and depression (p = 0.026) was evaluated in older patients. CONCLUSION: Long-term outcome perceptions after moderate to severe TBI presented in this study question current views of deteriorated recovery for the immature brain. The sustained TBI impact seemed not to reduce the child’s ability to overcome the suffered impairment measured by questionnaire based psychological, physical and health related outcome scores. These results distinguish the relevance of rehabilitation and family support in the long term.
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spelling pubmed-39417742014-03-05 Physical and psychological long-term outcome after traumatic brain injury in children and adult patients Andruszkow, Hagen Deniz, Ezin Urner, Julia Probst, Christian Grün, Orna Lohse, Ralf Frink, Michael Krettek, Christian Zeckey, Christian Hildebrand, Frank Health Qual Life Outcomes Research BACKGROUND: Several studies have indicated that younger age is associated with worse recovery after pediatric traumatic brain injury (TBI) compared to elder children. In order to verify this association between long-term outcome after moderate to severe TBI and patient’s age, direct comparison between different pediatric age groups as well as an adult population was performed. METHODS: This investigation represents a retrospective cohort study at a level I trauma center including patients with moderate to severe, isolated TBI with a minimum follow-up of 10 years. According to their age at time of injury, patients were divided in pre-school (0–7 years), school (8–17 years) and adult (18–65 years) patients. Physical examination and standardized questionnaire on physical and psychological aspects (Glasgow Outcome Scale, Barthel Index, Impact of Event Scale, Hospital Anxiety and Depression Scale, short form 12) were performed. RESULTS: 135 traumatized patients were included. Physical and psychological long-term outcome was associated with injury severity but not with patients’ age at time of injury. Outcome recovery measured by Glasgow Outcome Scale was demonstrated with best results for pre-school aged children (p = 0.009). According to the Hospital Anxiety and Depression Scale an increased incidence of anxiety (p = 0.010) and depression (p = 0.026) was evaluated in older patients. CONCLUSION: Long-term outcome perceptions after moderate to severe TBI presented in this study question current views of deteriorated recovery for the immature brain. The sustained TBI impact seemed not to reduce the child’s ability to overcome the suffered impairment measured by questionnaire based psychological, physical and health related outcome scores. These results distinguish the relevance of rehabilitation and family support in the long term. BioMed Central 2014-02-26 /pmc/articles/PMC3941774/ /pubmed/24571742 http://dx.doi.org/10.1186/1477-7525-12-26 Text en Copyright © 2014 Andruszkow et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research
Andruszkow, Hagen
Deniz, Ezin
Urner, Julia
Probst, Christian
Grün, Orna
Lohse, Ralf
Frink, Michael
Krettek, Christian
Zeckey, Christian
Hildebrand, Frank
Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title_full Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title_fullStr Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title_full_unstemmed Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title_short Physical and psychological long-term outcome after traumatic brain injury in children and adult patients
title_sort physical and psychological long-term outcome after traumatic brain injury in children and adult patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941774/
https://www.ncbi.nlm.nih.gov/pubmed/24571742
http://dx.doi.org/10.1186/1477-7525-12-26
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