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Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species

BACKGROUND: Aflatoxin B(1) (AFB(1)) is a highly toxic and hepatocarcinogenic metabolite produced by Aspergillus species. Some natural products are known to kill fungi and destroy toxins and toxin-producing agents. OBJECTIVES: The purpose of this study is to provide experimental data on the antifunga...

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Autores principales: Mohammadpour, Hossein, Moghimipour, Eskandar, Rasooli, Iraj, Fakoor, Mohammad Hadi, Alipoor Astaneh, Shakiba, Shehni Moosaie, Sara, Jalili, Zeynab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: DocS 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941858/
https://www.ncbi.nlm.nih.gov/pubmed/24624154
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author Mohammadpour, Hossein
Moghimipour, Eskandar
Rasooli, Iraj
Fakoor, Mohammad Hadi
Alipoor Astaneh, Shakiba
Shehni Moosaie, Sara
Jalili, Zeynab
author_facet Mohammadpour, Hossein
Moghimipour, Eskandar
Rasooli, Iraj
Fakoor, Mohammad Hadi
Alipoor Astaneh, Shakiba
Shehni Moosaie, Sara
Jalili, Zeynab
author_sort Mohammadpour, Hossein
collection PubMed
description BACKGROUND: Aflatoxin B(1) (AFB(1)) is a highly toxic and hepatocarcinogenic metabolite produced by Aspergillus species. Some natural products are known to kill fungi and destroy toxins and toxin-producing agents. OBJECTIVES: The purpose of this study is to provide experimental data on the antifungal activity of cumin oils and their components that could be considered suitable for application in foods and drugs. MATERIALS AND METHODS: The essential oil (EO) of Cuminum cyminum L. collected from Alborz Mountain, Iran, was obtained by hydro-distillation. The oil was analyzed by gas chromatography (GC) and chromatography/mass spectrophotometry (GC/MS). The antifungal activity of the oil was studied with regard to the inhibition of the growth of Aspergillus flavus PICC-AF39 , Aspergillus flavus PICC-AF24, Aspergillus parasiticus NRRL-2999 and Aspergillus niger. The minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations of the oil were determined. RESULTS: α–Pinene (29.2%), limonene (21.7%), 1,8-cineole (18.1%), linalool (10.5%), linalyl acetate (4.8%), and α-terpineole (3.17%) were the major components of the essential oil from C. cyminum L., and the oil showed a strong inhibitory effect on fungal growth. CONCLUSIONS: Essential oils could be safely used as preservatives in pharmaceuticals as well as health and food products to protect them against toxigenic fungal infections.
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spelling pubmed-39418582014-03-12 Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species Mohammadpour, Hossein Moghimipour, Eskandar Rasooli, Iraj Fakoor, Mohammad Hadi Alipoor Astaneh, Shakiba Shehni Moosaie, Sara Jalili, Zeynab Jundishapur J Nat Pharm Prod Original Article BACKGROUND: Aflatoxin B(1) (AFB(1)) is a highly toxic and hepatocarcinogenic metabolite produced by Aspergillus species. Some natural products are known to kill fungi and destroy toxins and toxin-producing agents. OBJECTIVES: The purpose of this study is to provide experimental data on the antifungal activity of cumin oils and their components that could be considered suitable for application in foods and drugs. MATERIALS AND METHODS: The essential oil (EO) of Cuminum cyminum L. collected from Alborz Mountain, Iran, was obtained by hydro-distillation. The oil was analyzed by gas chromatography (GC) and chromatography/mass spectrophotometry (GC/MS). The antifungal activity of the oil was studied with regard to the inhibition of the growth of Aspergillus flavus PICC-AF39 , Aspergillus flavus PICC-AF24, Aspergillus parasiticus NRRL-2999 and Aspergillus niger. The minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations of the oil were determined. RESULTS: α–Pinene (29.2%), limonene (21.7%), 1,8-cineole (18.1%), linalool (10.5%), linalyl acetate (4.8%), and α-terpineole (3.17%) were the major components of the essential oil from C. cyminum L., and the oil showed a strong inhibitory effect on fungal growth. CONCLUSIONS: Essential oils could be safely used as preservatives in pharmaceuticals as well as health and food products to protect them against toxigenic fungal infections. DocS 2012-05-28 2012 /pmc/articles/PMC3941858/ /pubmed/24624154 Text en Copyright © 2012 DocS. All rights reserved. http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mohammadpour, Hossein
Moghimipour, Eskandar
Rasooli, Iraj
Fakoor, Mohammad Hadi
Alipoor Astaneh, Shakiba
Shehni Moosaie, Sara
Jalili, Zeynab
Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title_full Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title_fullStr Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title_full_unstemmed Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title_short Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species
title_sort chemical composition and antifungal activity of cuminum cyminum l. essential oil from alborz mountain against aspergillus species
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941858/
https://www.ncbi.nlm.nih.gov/pubmed/24624154
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