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The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys

BACKGROUND: Boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. OBJECTIVES: This study focused on the effects of Boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examine...

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Autores principales: Azemi, Mohamad Ebrahim, Namjoyan, Foroogh, Khodayar, Mohammad Javad, Ahmadpour, Forouzan, Darvish Padok, Azam, Panahi, Marziyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: DocS 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941871/
https://www.ncbi.nlm.nih.gov/pubmed/24624177
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author Azemi, Mohamad Ebrahim
Namjoyan, Foroogh
Khodayar, Mohammad Javad
Ahmadpour, Forouzan
Darvish Padok, Azam
Panahi, Marziyeh
author_facet Azemi, Mohamad Ebrahim
Namjoyan, Foroogh
Khodayar, Mohammad Javad
Ahmadpour, Forouzan
Darvish Padok, Azam
Panahi, Marziyeh
author_sort Azemi, Mohamad Ebrahim
collection PubMed
description BACKGROUND: Boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. OBJECTIVES: This study focused on the effects of Boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. MATERIALS AND METHODS: The antioxidant capacity of plant extract was performed using FRAP assay. Diabetic and control rats were administered 200, 400, and 600 mg/kg Boswellia serrata extract. Vaginal plaque was mentioned as a positive sign of pregnancy ;and treatment started with extract or vehicle from 1th to 17th day of gestation by gastric gavage. Blood glucose was measured during 17 days. RESULTS: The Administration of Boswellia serrata in diabetic rats significantly decreased the level of blood glucose and HbA1c after 17th days (P ≤ 0.01). In diabetic group that received no treatment, the abortion of fetus spontaneous was 19.14%. The percentage of absorptions significantly was elevated in vehicle-treated diabetic rats, in comparison with vehicle- treated healthy rats. In the diabetic group, separated necrosis of hepatocytes, anarchism of liver plates, and lymphocytic inflammation were improved. Diabetic complications were not seen and the severity of damage was reduced. These damages include: lymphocytic inflammation in the port areas, irregularities, apoptosis of liver cells, and dilatation of the sinusoids. CONCLUSIONS: The results suggest that Boswellia serrata extract has the antidiabetic effects and can prevent the complications of diabetes in the kidneys and liver.
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spelling pubmed-39418712014-03-12 The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys Azemi, Mohamad Ebrahim Namjoyan, Foroogh Khodayar, Mohammad Javad Ahmadpour, Forouzan Darvish Padok, Azam Panahi, Marziyeh Jundishapur J Nat Pharm Prod Research Article BACKGROUND: Boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. OBJECTIVES: This study focused on the effects of Boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. MATERIALS AND METHODS: The antioxidant capacity of plant extract was performed using FRAP assay. Diabetic and control rats were administered 200, 400, and 600 mg/kg Boswellia serrata extract. Vaginal plaque was mentioned as a positive sign of pregnancy ;and treatment started with extract or vehicle from 1th to 17th day of gestation by gastric gavage. Blood glucose was measured during 17 days. RESULTS: The Administration of Boswellia serrata in diabetic rats significantly decreased the level of blood glucose and HbA1c after 17th days (P ≤ 0.01). In diabetic group that received no treatment, the abortion of fetus spontaneous was 19.14%. The percentage of absorptions significantly was elevated in vehicle-treated diabetic rats, in comparison with vehicle- treated healthy rats. In the diabetic group, separated necrosis of hepatocytes, anarchism of liver plates, and lymphocytic inflammation were improved. Diabetic complications were not seen and the severity of damage was reduced. These damages include: lymphocytic inflammation in the port areas, irregularities, apoptosis of liver cells, and dilatation of the sinusoids. CONCLUSIONS: The results suggest that Boswellia serrata extract has the antidiabetic effects and can prevent the complications of diabetes in the kidneys and liver. DocS 2012-10-07 2012 /pmc/articles/PMC3941871/ /pubmed/24624177 Text en Copyright © 2012 School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Azemi, Mohamad Ebrahim
Namjoyan, Foroogh
Khodayar, Mohammad Javad
Ahmadpour, Forouzan
Darvish Padok, Azam
Panahi, Marziyeh
The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title_full The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title_fullStr The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title_full_unstemmed The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title_short The Antioxidant Capacity and Anti-diabetic Effect of Boswellia serrata Triana and Planch Aqueous Extract in Fertile Female Diabetic Rats and the Possible Effects on Reproduction and Histological Changes in the Liver and Kidneys
title_sort antioxidant capacity and anti-diabetic effect of boswellia serrata triana and planch aqueous extract in fertile female diabetic rats and the possible effects on reproduction and histological changes in the liver and kidneys
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941871/
https://www.ncbi.nlm.nih.gov/pubmed/24624177
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