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Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis
BACKGROUND: Periodontitis is a major problem that affects a large number of patients in the society. Various treatment alternatives have been proposed to control this pathologic condition. Streptococcus sanguis is one of the countless pathogens involved in periodontitis. OBJECTIVES: The current stud...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
DocS
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941873/ https://www.ncbi.nlm.nih.gov/pubmed/24624172 |
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author | Khosropanah, Hengameh Bazargani, Abdollah Ebrahimi, Hooman Eftekhar, Kimia Emami, Zahra Esmailzadeh, Samira |
author_facet | Khosropanah, Hengameh Bazargani, Abdollah Ebrahimi, Hooman Eftekhar, Kimia Emami, Zahra Esmailzadeh, Samira |
author_sort | Khosropanah, Hengameh |
collection | PubMed |
description | BACKGROUND: Periodontitis is a major problem that affects a large number of patients in the society. Various treatment alternatives have been proposed to control this pathologic condition. Streptococcus sanguis is one of the countless pathogens involved in periodontitis. OBJECTIVES: The current study aimed to assess the efficacy of pineapple extract per se and in synergy with vancomycin on the growth activity of S. Sanguis. MATERIALS AND METHODS: An experimental study was designed to determine the minimum inhibitory concentration (MIC) of Pineapple extract per se and in conjunction with vancomycin. The study was carried out in three stages. Serial concentrations of the aqueous pineapple extract, vancomycin, and pineapple plus vancomycin were prepared by broth microdilution technique respectively and were exposed to the standard laboratory strain of S. sanguis (10556 ATCC). The lowest concentration of the pineapple extract and the mixed pineapple/vancomycin solution which inhibited bacterial growth was recorded as the MIC. RESULTS: The minimum inhibitory concentration of vancomycin was determined 1 µg/ ml. The pineapple extract failed to show any inhibitory effects per se, however, once added to vancomycin, it reduced the MIC to 0.5µg/ml. CONCLUSION: Prescription of pineapple extract along with antibiotics increases the antibacterial effects of the drug, therefore reduces the minimum inhibitory concentration of the antibiotic. |
format | Online Article Text |
id | pubmed-3941873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | DocS |
record_format | MEDLINE/PubMed |
spelling | pubmed-39418732014-03-12 Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis Khosropanah, Hengameh Bazargani, Abdollah Ebrahimi, Hooman Eftekhar, Kimia Emami, Zahra Esmailzadeh, Samira Jundishapur J Nat Pharm Prod Research Article BACKGROUND: Periodontitis is a major problem that affects a large number of patients in the society. Various treatment alternatives have been proposed to control this pathologic condition. Streptococcus sanguis is one of the countless pathogens involved in periodontitis. OBJECTIVES: The current study aimed to assess the efficacy of pineapple extract per se and in synergy with vancomycin on the growth activity of S. Sanguis. MATERIALS AND METHODS: An experimental study was designed to determine the minimum inhibitory concentration (MIC) of Pineapple extract per se and in conjunction with vancomycin. The study was carried out in three stages. Serial concentrations of the aqueous pineapple extract, vancomycin, and pineapple plus vancomycin were prepared by broth microdilution technique respectively and were exposed to the standard laboratory strain of S. sanguis (10556 ATCC). The lowest concentration of the pineapple extract and the mixed pineapple/vancomycin solution which inhibited bacterial growth was recorded as the MIC. RESULTS: The minimum inhibitory concentration of vancomycin was determined 1 µg/ ml. The pineapple extract failed to show any inhibitory effects per se, however, once added to vancomycin, it reduced the MIC to 0.5µg/ml. CONCLUSION: Prescription of pineapple extract along with antibiotics increases the antibacterial effects of the drug, therefore reduces the minimum inhibitory concentration of the antibiotic. DocS 2012-10-07 2012 /pmc/articles/PMC3941873/ /pubmed/24624172 Text en Copyright © 2012 School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences http://creativecommons.org/licenses/by/3/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Khosropanah, Hengameh Bazargani, Abdollah Ebrahimi, Hooman Eftekhar, Kimia Emami, Zahra Esmailzadeh, Samira Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title | Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title_full | Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title_fullStr | Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title_full_unstemmed | Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title_short | Assessing the Effect of Pineapple Extract Alone and in Combination With Vancomycin on Streptococcus sanguis |
title_sort | assessing the effect of pineapple extract alone and in combination with vancomycin on streptococcus sanguis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941873/ https://www.ncbi.nlm.nih.gov/pubmed/24624172 |
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